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Position: Senior Associate Scientist, Discovery Immunology

Location: Princeton, NJ

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.     

The Immunology and Cardiovascular (ICV) Thematic Research Center (TRC) at BMS is one of the fundamental Research and Early Development (R&ED) units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS’s internal innovation engine that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities. We work closely with our R&ED colleagues in clinical and non-clinical development, project leadership, translational medicine, and informatics to advance therapies based on a deep understanding of causal human biology. Furthermore, we collaborate across the biopharmaceutical ecosystem to establish partnerships that complement our internal expertise.

Position Summary

Bristol-Myers Squibb is seeking a highly motivated Senior Associate Scientist to join the Discovery Biology Immunology and In Vivo Pharmacology group at the Immunology and Cardiovascular Thematic Research Center located in Lawrenceville, NJ. The qualified candidate will possess the ability to work across a highly matrixed environment to advance drug discovery programs and will be responsible for developing and executing in vivo and ex vivo strategies using a wide range of animal disease models. The candidate must have hands on expertise in executing rodent models of disease from in vivo dosing and ex vivo disease end point analysis. The focus of this position will be the in vivo and ex vivo evaluation of novel therapeutic agents including large and small molecules that will support these drug discovery efforts; additional responsibilities will include identification and validation of novel disease and target specific biomarkers and development of new pharmacodynamic endpoints and disease models for autoimmune indications. The desired candidate will demonstrate sophisticated scientific thinking and have the enthusiasm and capacity to rise to challenges. A strong work ethic, good judgement and ability to work efficiently in a team setting are key qualities in the successful candidate. 

The position is a hands-on, laboratory-based role. The candidate is expected to be able to plan, design, develop methodologies and execute experiments according to plans and protocols with appropriate supervision.

Key Responsibilities

• Execute inflammatory or autoimmune animal disease models to support in vivo pharmacology and biology studies.
• Perform rodent dosing (PO, IP, IV, SC etc.) and tissue collection for ex vivo analysis.
• Develop, troubleshoot, and execute cellular and immunological assays with primary immune cells or cell lines.
• Perform techniques including sterile cell culture, multiplex ELISA, RNA isolation and RT-qPCR. Isolate mononuclear cells from tissues and phenotype cells and cellular responses using multicolor flow cytometry.
• Design and execute well-controlled experiments, perform data analysis, and summarize findings to the team.
• Collaborate alongside a cross-functional team with experts