Director, Portfolio Management

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines is seeking a motivated individual with a scientific background to play a critical role as the lead for Portfolio Management within the Pharmaceutical Development and Manufacturing (PDM) organization. This person will lead a cross functional team of professionals to develop an enterprise-focused strategy for PDM and provide clarity for the functional leaders and decision makers within PDM enabling strategic alignment and business priorities. This includes leading enterprise and PDM-focused strategic analysis projects and key initiatives.

Responsibilities:

• Facilitate cross-functional meetings partnering with the Corporate PM team and other PDM functional leads to develop, adapt and drive the product strategy.

• Maintain a strategic and accurate view of RevMed’s product portfolio, including initiative status, impact, and maturity. Prepare and continuously improve regular and ad hoc portfolio reports and dashboards for key stakeholders.

• Lead long range planning for all clinical and commercial projects (3-5 years horizon) based on clinical/commercial demand, supply chain risks, CDMOs capacity, lifecycle management (LCM) changes, and market approvals. Analyze portfolio trends, risks, and opportunities to support strategic decision-making and continuous improvement.

• Manage an integrated product plan which considers near and long-term cross functional impacts as well as region and country perspectives. Support portfolio planning and prioritization activities in alignment with drug substance (DS), analytical development & QC (ADQC), drug product (DP), supply chain (SC), CMC PM, CMC regulatory and quality (QA), based on corporate business priorities and to ensure overall PDM goals are met. Work with functional areas to manage program level resource demand forecasting.

• Collaborate with CMC PM to develop integrated, cross-functional program timelines, budgets and scenarios for RevMed’s Discovery, emerging, and clinical programs, focusing on immediate and short-term (<2 years) strategic planning horizon to support PDM business goals.

• Integrate the various cross-functional timelines to a single global program timeline that is maintained in real time within the portfolio management system and can be accessed by finance and management as necessary to make decisions. Collaborate closely with product leads and stakeholders to enhance portfolio alignment, visibility, and strategic communication efforts.

• Interface with financial planning team to ensure changes in budgets are captured in the forecast models. Manage cross functional team inputs for annual budgets, reforecasts, and long-range plans.

• Define and maintain KPIs to track progress, impact, and resource utilization across PDM.

• Identify, plan, and implement key process improvement projects to streamline operations through improved quality, reduced costs, increased productivity, and improved cycle time by reducing waste, rework, etc. resulting in significant business improvement and customer satisfaction.

• Consult with the PDM functional leaders and teams across operations to identify, diagnose, and problem solve organizational development and effectiveness problems and solutions.

• Participate in supply chain risk assessment, identify and monitor potential inventory risks (e.g., single-source suppliers, long lead-time parts), develop mitigation strategies such as buffer stock, alternate sourcing, etc.

Required Skills, Experience and Education:

• B.Sc. with 12 years or M.Sc. in scientific field with 10+ years of experience in pharmaceutical strategic sourcing and/or supply chain.

• Experience managing both strategic and tactical/operational projects.

• Working knowledge of and experience in clinical manufacturing, regulatory, QA, and cGMP requirements for small molecules.

• Working knowledge of small molecule drug development and commercialization, including, but not limited to, oral solid dosage form development and manufacturing, scale-up, and validation.

• Working knowledge of pharma end-to-end supply chain, with oral solid dosa