Sr. Scientist, Screening & Compound Profiling

Job Description

The Screening & Compound Profiling group at our Research Laboratories site in Rahway, NJ is looking for a highly motivated, talented and innovative Senior Scientist with a strong background in the development of cellular assays to support phenotypic and target-based small molecule screens, high-content imaging and functional genomic screening, with the goal of identifying novel targets and molecules to drive our drug discovery pipeline across multiple therapeutic areas.

Key Responsibilities:

• Design, plan and execute robust scientific research activities utilizing cell-based assays ‘at-scale’ to accelerate lead discovery in the identification of molecules and targets via small molecule and CRISPR screens

• Develop arrayed CRISPR screening applications in cell lines as well as complex disease-relevant models (primary cells, co-cultures, 3D culture)

• Focus on high throughput (HT)-complex cell models (3D, iPSC, co-culture systems) to enable the development of ‘assays at scale’

• Represent Screening & Compound Profiling on cross-functional project teams influencing strategic direction with data/progress updates & insight

• Contribute to a high-performance culture of inclusion, collaboration, engagement and self-accountability

Education:

• PhD with 0-3 years of experience, Master's Degree with 3-6 years of experience or a Bachelor's Degree with >10 years of experience in assay development and high throughput screening, with the ability to succeed in a collaborative, highly matrixed environment

Required Skills & Experience:

Some combination of the below skills

• Hands-on experience in the areas of cellular assay development with proficiency in high-content screening and image analysis using primary cultures and cell lines

• Experience in development, execution and analysis of arrayed CRISPR screens

• Extensive development and miniaturization of cell-based assays (384w/ 1536w) using liquid handlers and detectors to support small molecule profiling.

• Demonstrated ability to work under tight timelines and independently execute experimental tasks.

• Guidance of scientific operations, strategy, and communication with a track record of collaboration on multidisciplinary teams in one or more therapeutic area(s).

• Passion for fostering a diverse and inclusive culture and contributing to the growth and success of colleagues.

• Excellent verbal, written and interpersonal communication skills with a proven track-record of maintaining strong relationships with stakeholders.

Preferred Skills and Experience:

• Understanding and application of image and data analysis using both traditional methods as well as AI/ML

• Collaboration to identify, evaluate, and recommend novel and cutting-edge assay development strategies to drive programs in areas including, but not limited to, high throughput-complex cell models, Cell Painting, CRISPR and ML/AI.

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.