Senior Scientist II, Biologics Drug Product Development

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

Background of Biologics Drug Product Development

The Biologics Drug Product Development (BIO DPD) team develops antibody drug conjugates (ADC) and other biologics by state-of-the-art formulation and analytical technologies. We create valuable intellectual property through new formulation compositions, cost effective manufacturing processes and prepare and defend CMC (Chemistry, Manufacturing and Control) regulatory content.

We are looking for a highly motivated person to support Developability assessments for candidate molecules across a range of modalities. The candidate will support early-stage assessment of candidates coming out of the Discovery pipeline. In this role, the candidate will be part of a global team and will work closely with scientists from multiple functional areas, including Discovery, Analytical, and Process R&D.

Your Responsibilities:

• Characterization of Oligonucleotides (siRNA, mRNA), monoclonal antibodies, Antibody-Conjugates (various payloads), novel multi-specifics, and gene therapies via LCMS and physiochemical assessments
• Employ modern LC-MS instruments and techniques to understand degradation pathways and gain insight into therapeutic biologic molecules and assess their quality
• Experience evaluating the stability (chemical & physical) of biologics against solution conditions (pH, ionic strength, temperature, light, etc.) using standard analytical approaches
• Compilation and assessment of analytical data regarding function and stability of molecules to support candidate screening in a high throughput manner. Elucidation of structure and impurity/variant characterization of protein and oligonucleotide-based