Senior Medical Director

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines Senior Medical Directors are responsible for formulating clinical development strategy and ensuring effective execution of this plan for the assigned molecule(s)/combination(s)/indication(s).  Revolution Medicines has a robust research pipeline from discovery to clinic, and we are working rigorously to leverage this for the greatest possible impact for patients. As a clinician and scientist, you will be bridging the basic research with clinical development strategy in this scientifically rich environment.

In addition, the Senior Medical Director will have responsibilities in:

Clinical Development Planning

• Maintains the highest standards of scientific and clinical knowledge in the specific therapeutic area(s) of assignment.

• Stays informed and up to date of internal and external developments, trends, and other dynamics relevant to the clinical development plan, and maintains a current view of the relevant disease area(s) to inform strategy.

• Collaborates with external stakeholders such as clinical investigators and scientists.

• Participates in the Clinical Development Steering Team to review, discuss, and provide clinical and scientific input regarding early clinical development plans company/portfolio wide.

• Works with external investigators to advise on and evaluate Investigator Sponsored Trials.

Clinical Development Implementation

• Provides the clinical and expert input in the development of clinical sections of Investigator Brochures, presentations, and other materials.

• Regularly engages with the relevant external investigators; participates in the identification and selection of appropriate external investigators and sites.

• Acts as the medical monitor for assigned studies.

• Conducts ongoing reviews of medical/safety data.

• Collaborates within a multidisciplinary team including biostatisticians and programmers to develop study analytics and data management plans.

• Collaborates with the Translational Medicine team to strategize, design, and implement biomarker plans.

• Reviews study data to ensure correct medical/scientific data interpretation for interim and final study reporting.

• Collaborates with relevant team members to support regulatory interactions such as IND filing, intermittent safety updates, and End of Phase 1 Meetings.

Required Experience, Skills, and Education:

• M.D. or M.D./Ph.D. with relevant clinical training required. M.D./Ph.D. with oncology relevant postdoctoral training and/or research experience a plus.

• Minimum 10+ years’ experience in pharma/biotech clinical development OR is a recognized expert in the field.

• Experience working with the principles and techniques of data analysis, interpretation, and clinical relevance.

• A dedication to the RevMed core values:

  • Tireless Commitment to Patients.

  • Transformative Science.

  • Exceptional Together.

  • Total Integrity.

  • Inclusiveness and Fairness.

• Impeccable sense of ethics and scientific rigor.

• Excellent judgment and decision-making skills with outstanding attention to detail.

• Curiosity and a strong drive to grow.

• Strong written & verbal communication with good interpersonal and influencing skills.

• Excellent project management skills. Ability to prioritize multiple tasks and goals to ensure their timely and effective completion.

Preferred Skills:

• Recognized expert in the field.

• Academic/teaching background a plus.

• Prior medical monitoring experience.

• Phase III experience as medical monitor or clinical scientist.

• Option to travel globally for conferences (<15%)

The base salary range for this full-time position is $300,000 to $350,000 for candidates based at our headquarters in Redwood City, CA. The range displayed on each j