Sr. Scientist, Neuroimmunology

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:

Role will be leading a team and collaborating with cross-functional areas to drive project execution and contribute to portfolio advancement. This individual is expected to actively contribute to scientific advancements both internally and externally.

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Your Contributions (include, but not limited to):

• Designs and performs multiple experiments to support scientific activities and project goals involving cell including primary human leukocytes, mouse splenocytes and biochemical assays

• Generates and interprets data and works with complex assay system, with a strong understanding of advanced data analysis and statistical tests

• Manges advanced cell-based assay development, including primary cells, coculture and ex vivo tissues

• Independently sets up the in vitro assays to understand the cellular functions of innate and adaptive immune cells as well as the cell-cell interaction

• Advanced experience in isolating primary immune cells from various organs in experimental animal models.

• Expert experience in human PBMC isolation, lymphocyte proliferation, activation, cytokine secretion and differentiation assays

• Conduct multiple color flow cytometry assay including intracellular staining and prepare for cell sorting as well as flowcytometry data analysis

• Creates and maintains SOP’s and writes data summaries for experiments conducted

• Provides training and/or supervision to junior staff, as needed

• Other duties as assigned

Requirements:

• BS/BA degree and 4+ years of relevant experience OR

• MS degree and 2+ years OR

• PhD and some relevant experience; may include postdoc experience

• Advanced tissue culture techniques, including knowledge of human PBMC isolation, mouse splenocyte, iPCS and precursor cell handling and differentiation as well as hematopoietic cell differentiation

• Strong knowledge of NGS technologies, their implementation, and data analysis & relevant statistical t