Director, Employee Relations and HR Operations Partner

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

Amylyx is seeking a Director of Employee Relations and HR Operations Partner to help shape and support the dynamic growth of our organization. The incumbent will serve as a trusted advisor and central point of expertise for all employee relations matters while also playing a key role in supporting the broader HR function. This leader will design and oversee the frameworks, policies, and practices that shape the employee experience – ensuring our culture remains strong, inclusive, and high-performing as we scale.  In addition, this leader drives consistency, fairness, and compliance across the organization while strengthening our culture of trust, accountability and performance.

This individual will focus on the day-to-day realities of the employee journey—from navigating workplace challenges to reinforcing performance expectations—while partnering closely with the Talent Management & Development team (who leads onboarding, training, development, and coaching), and with HR Business Partners as the organization expands. The Director will bring balance: empathetic support for employees, clear guidance for managers, and sound judgment that protects the business.

Responsibilities

Employee Relations Leadership

• Lead the company’s employee relations strategy and practices, ensuring a fair, consistent, and values-based approach to all workplace matters.
• Conduct, oversee, and document internal investigations in collaboration with Legal and the CHRO.
• Advise leaders and managers on performance management, corrective action, and workplace conflict resolution.
• Partner with HR and Legal to ensure policies are up to date, employee-friendly, and compliant with applicable laws.
• Identify ER trends and proactively recommend training or process improvements to strengthen organizational health and prevent recurrence.
• Manage and resolve employee concerns, investigations, and corrective actions with discretion and integrity.
• Coach and develop HR team members and managers on effective employee relations practices and documentation standards.

HR Functional & Business Partnership Support

• Act as a connective point across the HR functions supporting HR Business Partners, Talent Acquisition, Total Rewards, and HRIS to ensure aligned, consistent delivery of HR programs.
• Partner with HRBPs to advise on organizational design, workforce planning, and performance-related interventions.
• Contribute to annual HR processes, including performance reviews, compensation planning, talent calibration, and engagement initiatives.
• Support cross-functional HR initiatives and special projects that advance HR infrastructure, operational excellence, and employee experience.
• Serve as a thought partner to the HR leadership team on policy interpretation, communications, and change-management efforts.

Compliance & Culture Stewardship

• Lead the development, administration and rollout of HR policies.
• Ensure compliance with federal, state, and local employment laws (e.g., EEO, FMLA, ADA, wage and hour).
• Partner closely with Legal on sensitive employee matters, audits, and risk assessments.
• Promote a culture of inclusion, accountability, and mutual respect that aligns with company values and business goals.
• Develop and deliver training for managers on policies, performance management, and respectful workplace behaviors.
• Partner with HR Business Partners to ensure consistent application across the organization.
• Collaborate with Legal and HR leadership on sensitive matters including terminations, restructures, and compliance audits.
• Serve as a point of guidance for the HR and Legal team on complex policy questions related to our employees. 

Flexibility & Growth Mindset

• Embrace the dynamic environment of a growing biotech organization, recognizing that responsibilities may evol