Associate Principal Scientist, Mass Spectrometry

Job Description

At our company, we are committed to improving the health and well-being of people around the world. As a leading global pharmaceutical company, we strive to make a difference through innovative research, discovery, and development of life-saving medications and vaccines. With over a century of experience and a steadfast dedication to scientific excellence, we have become a trusted name in the industry. Join our team and be a part of our mission to create a healthier future for all.

We are seeking a highly motivated and innovative Associate Principal Scientist to join our Biochemistry & Mass Spectrometry team within the Mass Spectrometry & Biophysics (MSB) Department in Quantitative Biosciences. Our team utilizes multidisciplinary techniques to characterize ligand-protein interactions and modulation of (target) protein function to support early-stage drug discovery across a broad spectrum of therapeutic modalities.

Applicants will ideally have a strong background in protein mass spectrometry and prior experience in hydrogen-deuterium exchange mass spectrometry (HDX-MS) or related techniques to characterize ligand-protein and protein-protein interactions. The successful candidate will be part of cross-functional teams and will collaborate across diverse therapeutic areas including Oncology, Immunology, Neuroscience, Cardiometabolic and Infectious Diseases.

Key Responsibilities:

• Utilize HDX-MS and other protein footprinting techniques to characterize protein higher order structure and dynamics, as well as ligand-protein and protein-protein interactions.

• Perform intact protein and peptide mapping experiments to identify cleavage patterns, covalent modification, PTMs and differential expression patterns.

• Collaborate with colleagues in our Biochemistry, Biophysics, BioNMR and Protein & Structural Chemistry teams to deliver an integrated view of protein conformation and interactions.

• Serve as a representative on cross-functional program teams with accountability for delivering progress updates, presenting data & contributing to strategic direction.

• Stay abreast of advancements in the field of protein and biophysical mass spectrometry and drive innovation through platform development, internal/external collaboration & long-range capability planning.

• Contribute to a high-performance culture of inclusion, collaboration, engagement and self-accountability.

• Promote the external reputation of our department through publications and participating in external symposia.

Minimum Education Required:

• Post-graduate degree in Analytical Chemistry, Structural Biology, Biochemistry or another related field with 5+ years of relevant industry experience: Ph.D. (5+ years), M.Sc. (7+ years) or B.Sc. (13+ years).

Essential Qualifications:

• Broad expertise in protein mass spectrometry/proteomics, including hands-on experience performing HDX-MS studies, is required.

• Ability to independently trouble-shoot hardware and software complications and liaise directly with field service engineers to resolve issues as needed.

• Experience performing technology evaluations & making recommendations on investments designed to maintain a leadership position in the field.

• Demonstrated passion for fostering a diverse and inclusive culture and contributing to the growth and success of colleagues.

• Strong external reputation as evidenced through high-impact publications, presentations, and scientific community engagement.

• Excellent verbal, written and interpersonal communication skills with a proven track-record of maintaining strong relationships with stakeholders.

Desirable Experience and Skills:

• Prior experience with additional structural mass spectrometry techniques for characterizing ligand-protein interactions such as FPOP, photoaffinity labeling and native mass spectrometry would be a significant advantage.

• Knowledge of structural techniques such as bioNMR, x-ray crystallography and cryo-electron microscopy is beneficial.

• Experience with classical protein biochemistry techniques including gel electrophoresis, western blotting, enzymatic digestion, protein/peptide fractionation, SEC, DLS, etc. is advantageous.

• Prior experience with membrane protein characterization is desirable.

NOTICE FOR INTERNAL APPLICANTS

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