Sr. Medical Director (MD), Translational and Experimental Medicine, Metabolic

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:

Medical expert responsible for the development of translational and early clinical research strategies and independent direction of Phase 1 and early Phase 2 (first-in-human and early proof-of-concept) clinical studies while working with cross-functional project teams (clinical project managers, preclinical/clinical pharmacology, biometrics, regulatory, drug safety). Responsible for the creation and execution of early clinical development plans that advance innovative therapies, particularly in metabolic disorders including but not limited to disorders affecting the endocrinological, immunologic, and/or neurologic systems.

Provides expert medical and scientific advice to advance the early development portfolio and help navigate the complex translational drug development landscape. Works closely with Research and Preclinical Development to develop and implement biomarkers and experimental medicine approaches necessary for effective evaluation of novel molecules in early human studies.

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Your Contributions (include, but are not limited to):

• For assigned programs, develops translational and early clinical development strategies and is accountable for the study design of Phase 1 and early Phase 2 clinical trials, leading preparation of clinical study synopses and serving as a major contributor to the writing of protocols/major amendments, the design of data collection systems, interpretation of clinical and biomarker data, and preparation of final clinical study reports. Engages with external experts and organizations as needed to achieve these aims

• Represents Medical/Clinical on the cross-functional Program Team as the Translational Medicine Lead. Accountable and responsible for the medical input to integrated development plans prepared by the Program Team, with primary emphasis on first-in-human and early proof-of-concept strategies

• Provides medical leadership to the Program Team and is accountable for driving execution of the early clinical development plan

• Develops and implements study protocols in conjunction with a multidisciplinary Development Team, incorporating