Senior Scientist 1, in Vivo Pharmacology

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

The Senior Scientist 1, In Vivo Pharmacology, will be responsible for providing in vivo pharmacology support to Endocrine Discovery teams including designing, conducting, and interpreting experiments to demonstrate efficacy and toxicity of novel small molecules in animal models.  The candidate will have a broad background in in vivo pharmacology and will contribute to several preclinical projects as well as the identification of new targets. 

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Design, conduct, and interpret in vivo experiments to evaluate the efficacy, pharmacokinetics, and safety of therapeutic candidate molecules in support of drug discovery programs with a focus on endocrine disease.
• Conceive of, research and develop new animal models of endocrine disease states.
• Demonstrate a high level of initiative to troubleshoot and accurately perform data analysis on in vivo studies.
• Participate in the exploration and evaluation of new targets in endocrinology.
• Analyze and present experimental data using Prism, Excel, MS Office or comparable software.
• Present findings to cross-functional internal groups, program team meetings, and at scientific conferences.
• Serve as an in vivo pharmacology lead for Endocrine Discovery programs.
• Manage outsourced studies and collaborations.
• Lead and supervise junior scientists.
• Contribute to scientific publications and in vivo pharmacology reports to support regulatory filings.
• Responsible for ensuring compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.
• Perform timely data verification and ensure accuracy for laboratory notebooks, protocols, reports, and regulatory filings.
• Willing to work some weekends and holidays as needed.
• Other duties as assigned.

Education and Experience:

Required:

• Ph.D. in Biology, Endocrinology, Behavioral Pharmacology, Physiology, Neuroscience, or related discipline with 3-5 years of relevant experience. Applicants with BS or MS degrees may apply but must demonstrate a minimum of 15 years of significant and relevant experience.
• Experience in designing and conducting rodent in vivo pharmacology studies
• Experience working in the pharmaceutical industry
• Hands on proficiency in rodent handling procedures and in vivo skills including dosing (IV, PO, SC), blood and tissue collection, necropsy, etc.
• Proficiency with basic surgical techniques
• Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature
• Able to effectively communicate and present summaries of research results to team members, and colleagues from other disciplines
• Must have a strong work ethic and be enthusiastic for animal and laboratory work
• Must be detail-oriented, punctual, reliable, and available on weekends when necessary
• Strong written and verbal communication skills and ability to work effectively in a multidisciplinary team environment
• Ability to work in a fast-paced environment and adapt to change

Preferred:

• Experience developing endocrinology in vivo models
• Experience with non-GLP rodent toxicity studies
• Experience managing direct reports

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee t