Director, Payer Marketing

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Title: Director, Payer Marketing

Location: Waltham, MA \ Conshohocken, PA

About the Role
The Director, Payer Marketing will lead the development of strategic, evidence-based payer value communication tools that support access and reimbursement for Madrigal Pharmaceuticals’ therapies in Metabolic Dysfunction-associated Steatohepatitis (MASH). This role translates complex clinical, economic, and real-world evidence into compelling value propositions for U.S. payers—across Commercial, Medicare, and Medicaid channels—while ensuring alignment with brand positioning and field execution strategies.

A key responsibility of this role is to develop and adapt value communication resources to meet the specific needs of the Key Account Director (KAD) and Regional Account Director (RAD) teams. This includes crafting tailored materials—such as payer value decks, cost-impact claims, and summary tools—that reflect the differentiated value of Rezdiffra in IDNs, GI super groups, and regional managed care organizations. By aligning content with local market dynamics, formulary criteria, and institutional drivers, the Director will enable both KADs and RADs to effectively communicate value and support account-level pull-through.

The Director will work cross-functionally with Market Access, Brand Marketing, HEOR, and Field Access teams to ensure value messages are consistent, credible, and responsive to evolving payer scrutiny, policy shifts, and competitive pressures. This role is critical to maintaining Rezdiffra’s leadership position by enabling internal stakeholders to deliver tailored, high-impact access communications across customer archetypes.

Key Responsibilities

Value Communication Strategy & Execution
• Develop and execute comprehensive value communication strategies to drive payer coverage, reimbursement, and pull-through across Commercial, Medicare, and Medicaid markets.
• Lead the development of payer value stories and other messaging resources supported by clinical evidence and health economics data to demonstrate the differentiated value of Madrigal’s therapies.
• Integrate brand strategy into payer messaging by partnering closely with Brand Marketing to ensure alignment across patient, HCP, and payer communication channels.
• Tailor value narratives to specific payer archetypes and coverage scenarios, anticipating access barriers and articulating clear justifications for formulary inclusion.
• Continuously refine the overall value proposition based on evolving payer needs, policy shifts, and competitor developments.
• Collaborate with HEOR and Medical to ensure alignment of payer messaging with evidence generation and scientific narratives.

• Translate clinical trial data, real-world evidence, and economic analyses into actionable insights for payer audiences.
• Oversee the development of cost-effectiveness analyses, budget impact models, and population health value tools in partnership with HEOR.

• Work with the commercial team to embed access and affordability messaging into HCP engagement plans and marketing tactics.

• Design omnichannel content strategies that reinforce the product value proposition via digital, email, portal, journal, and conference-based touchpoints.
 

Payer Tools & Field Enablement
• Create payer engagement materials for National Access Directors (NADs), Regional Access Directors (RADs), and Key Account Directors (KADs), including objection handlers, FAQs, and scenario-based field tools.
• Develop and lead training initiatives to ensure