Senior Facilities Engineering Manager

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!  

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics. 

Why Join Us? 

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy. 

• Collaborative Culture: Be part of a diverse team dedicated to your professional growth. 

• Global Impact: Contribute to therapies that make a lasting impact on patients globally. 

Role Overview 

We are seeking a Senior Facilities Engineering Manager to lead the Facilities Engineering team responsible for ensuring GMP manufacturing equipment, utilities, and facility assets are qualified and validated, reliable and available for production and lab operations, ready for Phase III manufacturing and commercial launch, and continuously improved using reliability engineering principles. This role bridges Facilities Engineering, CMC Manufacturing, CSV, and Quality (OQA, QAV).

Schedule: Monday to Friday; 8:00 am – 5:00 pm; on-call support as needed

Reports to: Director, Facilities, Engineering, & Asset Lifecycle 

Location: 13203 Murphy Road Suite 100 Stafford, TX 77477 

Basic Qualifications: 

• Bachelors degree in Mechanical, Electrical, Chemical Engineering, or related field

• 7+ years in pharmaceutical or biotech engineering within a GxP regulated manufacturing or laboratory environment, with 5+ of those years directly leading teams

Preferred Qualifications:  

• Strong knowledge of FDA and cGMP requirements

• Deep experience with IQ/OQ/PQ with exposure to CSV interfaces

• Expertise in cleanrooms and critical utilities

• Experience supporting commercial biologics or cell therapy manufacturing

• Familiarity with CMMS, BMS/EMS, digital maintenance systems

• PMP or similar certification is advantageous

• Demonstrated understanding of 21 CFR Part 11, 21 CFR Part 210, 21 CFR Part 211, EU Annex 1, and USP

• Experience in writing and reviewing Deviations and CAPAs, investigations resulting from OOS/OOT, environmental excursions, lab investigations leading to Change Controls for QMS. 

In this role you will: 

• Lead validation and qualification of GMP manufacturing equipment, process utilities, HVAC systems, cleanrooms, compressed gases, etc.

• Oversee IQ, OQ, PQ, Requalification strategy, and Validation lifecycle management.

• Develop and manage preventive maintenance, predictive maintenance, reliability-centered maintenance, asset criticality analysis and equipment lifecycle planning to maximize equipment uptime, reduce unplanned downtime and improve overall equipment effectiveness.

• Support transition from late-stage clinical manufacturing to commercial operations

• Partner with Quality to manage deviations, lead equipment investigations, execute CAPAs, and support change control.

• Lead, mentor, and coach equipment validation engineers and reliability engineers.

• Manage engineering budgets and KPIs.

• Perform engineering duties when necessary

What do we offer?  

At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics 

Comprehensive Benefits:  

• Competitive rates for Health, Dental, and Vision Insurance 

• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment. 

• 12 company paid holidays