Senior Manager, Program Management

What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way?

About Vesalius

Vesalius Therapeutics is pioneering a revolutionary platform to generate breakthrough treatments for common diseases. Vesalius’ platform uses large-scale human genetics, genomics, stem cell studies, and artificial intelligence to uncover causal biology and identify optimal intervention points for new therapies. Efficiently identifying these intervention points and the patients most likely to benefit from these novel therapies will enable smaller, shorter clinical trials with a higher probability of success. Vesalius was founded in 2019 by Flagship Pioneering. For more information visit vesaliustx.com, or follow us on X and LinkedIn.

Position Summary

Vesalius Therapeutics is seeking a highly motivated and experienced Senior Manager, Program Management to drive operational excellence across our early-stage research and development programs. This role will provide critical program management leadership and cross-functional coordination to ensure the timely and efficient advancement of our therapeutic portfolio.

Reporting to the SVP of Strategy, the ideal candidate will thrive in a fast-paced, entrepreneurial biotech environment and bring experience managing cross-functional drug discovery or translational biology programs. This is a high-visibility role requiring both strategic thinking and strong execution capabilities.

Key Responsibilities

Program Planning & Execution

• Create and maintain detailed project plans, timelines, and budgets
• Identify critical path activities and proactively manage risks and dependencies.
• Track and monitor key milestones and decision points to drive delivery of project objectives.
• Coordinate with finance and project teams to track program budget and forecasts

Team Leadership & Communication

• Effectively communicate with team members, senior leaders and key stakeholders on the status, objectives, risks, and mitigation plans associated with projects.
• Ensure team members are aware of integrated project timelines and provide timely updates of status and cross-functional impact.
• Facilitate team meetings using project management best practices/tools to drive cross-functional communication, timely and effective decision making, and successful execution of project objectives.
• Organize and maintain team communications including meeting agendas, minutes, decision logs, dashboards, tasks lists, and risk analyses/mitigation strategies.
• Foster a culture of collaboration, accountability, and continuous improvement within project teams.

Operational Excellence

• Develop and implement tools, best practices, and standardized templates for efficient project execution and communication.
• Act as a central point of contact for cross-functional coordination, helping to streamline execution and manage complexity.

Qualifications

• Bachelor’s degree in life sciences, bioengineering, or a related field is required; advanced degree (MS, PhD, MBA) and/or PMP certification strongly preferred.
• 5+ years of relevant experience in the biotech or pharmaceutical industry, with at least 3 years in a program or project management role.
• Proven track record in early-stage R&D program execution, ideally involving genomics, data-driven discovery, or platform technologies.
• Deep understanding of the drug discovery and development process, particularly translational biology and preclinical research.
• Strong organizational, communication, and stakeholder management skills with an ability to synthesize complex information.
• Proficiency in program management tools (e.g., MS Project, Smartsheet, or equivalent) and collaboration platforms (e.g., SharePoint, Teams).

Desired Attributes

• Entrepreneurial mindset with the ability to adapt quickly and drive initiatives in a dynamic, fast-moving environment.
• Strong interpersonal and influence skills, with a passion for building and supporting high-performing teams.
• Comfortable with ambiguity and skilled in driving clarity and alignment among cross-functional stakeholders.
• A team player who thrives on collaboration and shared success.

Our Culture & Values

At Vesalius, we operate at the intersection of cutting-edge science, data, and medicine to reimagine drug discovery. Our team members are passionate, mission-driven, and collaborative. We believe in nurturing diverse perspectives, embracing bold ideas, and relentlessly pursuing transformative outcomes for patients.

About Flagship

Flagship Pioneering is