Sr. Associate Scientist, Translational Pharmacology

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals

Sr. Associate Scientist Translational Pharmacology

Job Description

This laboratory-based role presents an exciting opportunity to advance novel radiopharmaceutical therapies from bench to bedside. The successful candidate will be responsible for conducting in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, and therapeutic efficacy across various pipeline projects. These studies will include the assessment of radiopharmaceutical agents and other therapeutic modalities. In addition to in vivo work, the candidate will perform in vitro mechanistic experiments to explore translational aspects of treatment response. The ideal candidate will have strong hands-on experience in in vivo and in vitro pharmacology, demonstrate critical thinking, and possess excellent technical problem-solving skills. A collaborative mindset and enthusiasm for working in interdisciplinary teams are essential.

This role requires the ability and willingness to work with radioactive isotopes.

Job Responsibilities

• Essential duties and responsibilities include the following. Other duties may be assigned.
• Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents.
• Perform essential in vivo procedures, including cell culture, tumor cell and PDX fragment implantation, surgical modeling of physiological conditions, intravenous dosing, tumor and body weight monitoring, periodic blood collection and necropsy.
• Independently analyze and interpret experimental data, and present findings at project team meetings, departmental reviews, and company-wide forums.
• Conduct in vitro experiments post-training, including cell viability and cytotoxicity assays, proliferation analysis, mechanistic studies (e.g., apoptosis, DNA damage response), and pathway interrogation using molecular biology techniques.
• Maintain meticulous records of all experimental procedures, data, and observations in accordance with regulatory and internal standards.
• Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols.
• Contribute to experimental design and planning, helping to drive project milestones under tight timelines and dynamic priorities.
• Support translational and in vivo pharmacology efforts under the guidance of project leads, ensuring adherence to animal welfare guidelines and strategic prioritization of studies.
• Collaborate cross-functionally with teams in translational research, medicinal chemistry, and other scientific disciplines to advance pipeline objectives.
• Assist with laboratory operations, including inventory management, equipment maintenance, and compliance documentation.
• Uses AI tools to enhance individual productivity and quality of work

Education and Experience

• BS with 4+ years of experience or MS with 2+ years of experience in in vivo pharmacology, translational research, biology, molecular biology, or a related discipline, with hands-on laboratory experience.
• Prior experience working on translational or pharmacology projects in an industrial or academic setting is preferred.

Skills

• Hands-on experience with cell culture, tumor cell/fragment implantation, animal handling, surgery, dosing (