Senior Scientist, DMPK

Company Summary:

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

Position Summary:

The Senior Scientist will be responsible for developing in vitro assays to monitor lipid metabolic stability, in vivo ADME assays including metabolite identification, and PK/PD modeling to support research, non-clinical and clinical development programs for a variety of therapeutic indications. The ideal candidate must have excellent communication skills and is willing to work in a fast-paced work environment. We are searching for a driven, enthusiastic and self-motivated individual who is comfortable multitasking and working independently on various aspects of the platform. This individual will join a dynamic, rapidly growing, and highly collaborative team.

Key Responsibilities:

• Conduct in vitro metabolic stability assay for lipid in various biological matrices including liver S9, liver microsome and tissue homogenates.
• Characterize and quantitate lipids and lipid metabolites in various biological matrices including urine, feces, and plasma by LC-MS.
• Conduct metabolite identification, analyze, and interpret data to understand lipid metabolism.
• Design and execute experiments from sample preparation, LC-MS/MS operation to data analysis & interpretation.
• Conduct PK/PD analyses for non-GLP PK/PD study to support pre-clinical programs.
• Coordinate method transfer to CROs and serve as technical expert for method trouble shooting.
• Prepare research reports and contribute to the preparation of regulatory applications.
• Develop protocols and sample analysis procedures for new assays. Prepare bioanalytical and metabolite identification reports and data presentations.

Preferred Qualifications:

• Ph.D. degree with 4+ years of biotech/pharma/CRO experience in related field.
• In-depth knowledge in drug metabolism and pharmacokinetics of small molecule drugs is required.
• Hands on experience in LC-MS is required.
• Hands on experience in developing/conducting metabolic stability assays or metabolite identification is required.
• Excellent lab-based skills and the ability to work independently to analyze, interpret, and present data are required.
• Excellent organizational and communication skills.
• Ability to conduct multiple laboratory and project tasks efficiently.
• Ability to work in a team-oriented environment with flexibility.

Preferred Qualifications:

• Experience in metabolite identification is a plus.
• Knowledge and experience in specialty software for PK/PD analysis and modeling such as WinNonlin is a plus.
• Experience with biomolecule, gene therapy, or mRNA therapeutics is a plus.

More About Flagship Pioneering

Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

 

Recruitment & Staffing Agencies:  Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.  The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.   Any resume submitted b