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Head of Clinical Development (Vice President)
Krystal BiotechPittsburgh, United Statesfull_timeVerifiedPosted 24 Jul 2026
About the role
Head of Clinical Development (Vice President)
About Krystal Bio: At Krystal Biotech, we bring together the brightest and most eager minds to relentlessly pursue the discovery, development, manufacturing, and commercialization of genetic medicines to treat diseases with high unmet medical needs.
Founded in 2016, Krystal is distinguished in three powerful ways: science and technology using our patented gene therapy platform, innovative manufacturing supported by our commercial scale facilities, and a unique commercialization model that focuses on the patient’s end to end experience.
Krystal received U.S. FDA approval for the first and only redosable gene therapy treatment, VYJUVEK®, for the treatment of Dystrophic Epidermolysis Bullosa (DEB). Krystal continues to leverage our proprietary platform to rapidly advance a robust pipeline of investigational genetic medicines in respiratory, oncology, dermatology, and ophthalmology.
Krystal is headquartered in Pittsburgh, PA which is home to our two state-of-the-art CGMP manufacturing facilities with teams around the world and satellite offices in Switzerland, Germany, and Japan. We are a company built and run by people who care, are fearless in the face of a challenge, love the work they do, and practice the highest level of scientific integrity. As we grow, we are seeking team members that embody these values.
Job Description Summary:
Krystal Biotech, Inc. is seeking a Vice President of Clinical Development to lead parallel development programs in different multiple therapeutic areas from the clinic through product approval. The Vice President of Clinical Development will be an integral member of the Krystal Biotech clinical team, contributing significantly to the advancement of programs into and through the clinic, and be a part of a fast-paced cross-functional team to bring these therapies through development. The direct responsibilities of this position will cover Phase 1 through Phase 3 and post-approval activities, expanding and advancing the Company’s programs from early clinical trial development to proof-of-concept and commercialization. This Vice President will be in a high-profile and high-impact position, responsible for executing and delivering on critical clinical milestones, and will also be integral to the clinical development strategy. This role will be based in Krystal’s headquarters in Pittsburgh, PA.
Responsibilities will include, but are not limited to, the following:
About Krystal Bio: At Krystal Biotech, we bring together the brightest and most eager minds to relentlessly pursue the discovery, development, manufacturing, and commercialization of genetic medicines to treat diseases with high unmet medical needs.
Founded in 2016, Krystal is distinguished in three powerful ways: science and technology using our patented gene therapy platform, innovative manufacturing supported by our commercial scale facilities, and a unique commercialization model that focuses on the patient’s end to end experience.
Krystal received U.S. FDA approval for the first and only redosable gene therapy treatment, VYJUVEK®, for the treatment of Dystrophic Epidermolysis Bullosa (DEB). Krystal continues to leverage our proprietary platform to rapidly advance a robust pipeline of investigational genetic medicines in respiratory, oncology, dermatology, and ophthalmology.
Krystal is headquartered in Pittsburgh, PA which is home to our two state-of-the-art CGMP manufacturing facilities with teams around the world and satellite offices in Switzerland, Germany, and Japan. We are a company built and run by people who care, are fearless in the face of a challenge, love the work they do, and practice the highest level of scientific integrity. As we grow, we are seeking team members that embody these values.
Job Description Summary:
Krystal Biotech, Inc. is seeking a Vice President of Clinical Development to lead parallel development programs in different multiple therapeutic areas from the clinic through product approval. The Vice President of Clinical Development will be an integral member of the Krystal Biotech clinical team, contributing significantly to the advancement of programs into and through the clinic, and be a part of a fast-paced cross-functional team to bring these therapies through development. The direct responsibilities of this position will cover Phase 1 through Phase 3 and post-approval activities, expanding and advancing the Company’s programs from early clinical trial development to proof-of-concept and commercialization. This Vice President will be in a high-profile and high-impact position, responsible for executing and delivering on critical clinical milestones, and will also be integral to the clinical development strategy. This role will be based in Krystal’s headquarters in Pittsburgh, PA.
Responsibilities will include, but are not limited to, the following:
- Leading clinical development programs from the late preclinical stage to registration and completion of post-approval commitments.
- Work cross-functionally with Clinical Operations and/or vendors to successfully execute clinical trials and natural history studies. These activities may consist of coordination, collection, and analysis of clinical data and reporting, and providing ongoing medical monitoring for clinical trials, including assessment of eligibility criteria, toxicity management, and drug safety surveillance.
- Manage the preparation and/or review of data listings, summary tables, study results, study reports, clinical/regulatory/safety documents, investigator brochures, and clinical development plans.
- Interact with global regulatory agencies and have responsibility for authoring and/or reviewing relevant Pre-IND, IND, and BLA sections and generating responses.
- Close collaboration with academic institutions associated with the clinical development program.
- Engage with thought leaders, investigators, cooperative groups, and other experts in constructive scientific and clinical dialog around study design, study conduct, and interpretation of clinical results.
- Support patient recruitment on assigned clinical programs, including recruitment strategy and execution in tandem with clinical sites.
- Must be able to critically evaluate and understand the unmet medical needs in various therapeutic areas, outcome measures, treatment options, etc.
- Partner with internal and external key stakeholders to develop manuscripts for publication in peer-reviewed journals and preparation of presentations for scientific conferences as well as for clinical study investigator meetings and expert clinical advisory meetings.
- Collaborate with Medical Affairs in developing medical slide decks, educat
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