Multi-Omics Discovery Bioanalysis Director, Integrated Bioanalysis

Introduction to role

As a Director for Multi-omics in Discovery Bioanalysis, part of Integrated Bioanalysis in Clinical Pharmacology and Safety Sciences (CPSS), you will lead teams and devise strategies to embed the use of proteomics, metabolomics, and transcriptomics in support of safety biomarker discovery, safety screening, and wider application across the Integrated Bioanalysis function. You will lead scientists accountable for assay development, optimization, qualification, execution, and transfer of high-complexity assays using state-of-the-art instrumentation to support pre-clinical and clinical studies. This will incorporate pathway analysis, biomarker discovery, and safety risk assessment characterization. You will direct both internal delivery and oversee assay transfer and analysis to CRO partners.
 

You will manage a dynamic team in a matrixed environment working across the business. This role will be a key interface between our department and therapy area and excellence-function stakeholders. Working closely with our wider discovery bioanalysis organization, you will seek to maximize internal knowledge exchange and collaboration. You will be a strategic leader, able to influence at an enterprise level, and lead on the evaluation and development of innovative analytical platforms required to deliver to the portfolio based on your understanding of current and future project needs. This role will allow you to maintain our momentum in the delivery of fast proteomics, expand multi-omics in support of the acceleration of our portfolio, while also supporting interconnection of analysis for spatial biology, cellular omics, and advanced safety models. You will have the opportunity to have an immediate and lasting impact on our diverse pipeline.
 

Accountabilities

You will have a proven ability to develop strategy and be responsible for the successful operation of scientific activities of major significance to an organization. Based at our major R&D hub in Gaithersburg MD, US, the successful candidate will have leadership roles across laboratory groups and our vendor partners to ensure appropriate -omics methods are established. You will define our multi-omics strategy and play a key part in bringing innovative medicines to patients based on a deep understanding of multi-omics for safety and efficacy.
 

You will identify internal and external industry trends and anticipate future changes that impact scientific understanding in safety and efficacy. Reporting to the Head of Discovery Bioanalysis, you will be a champion for a culture of scientific curiosity and empowerment to build and support innovative research.

The right candidate will play a vital role in supporting the Integrated Bioanalysis Leadership team in making sound scientific and business decisions based on a balance of data, competitive environment, context analysis, and experience. You will ensure effective operations, resource capacity management, financial planning, and portfolio delivery.
 

In this role, you will need to proactively build and cultivate strong relationships across AstraZeneca and with external academic and corporate centers of excellence to help establish AstraZeneca as the partner of choice for collaborations. Leverage these partnerships to drive scientific and organizational innovation and performance beyond established approaches.

Essential Skills/Experience

• PhD in analytical chemistry, biochemistry, genomics molecular biology or related discipline with at least 10+ years of post-PhD experience or industry experience operating at this level

• Experience in managing multidisciplinary teams and overseeing and guiding experts employing multi-omic analysis platform to enable discovery and validation of metabolomic/lipidomic/proteomics biomarkers.

• Proven experience as a recognized scientific leader in an array of multi-omic techniques including development and execution of multi-omic strategies

• Technical expertise with an array of proteomics platforms including but not limited to high-resolution mass spectrometry (HRMS, ToF or Orbitrap), QqQ instruments, ligand binding assays, Olink, and other technology platforms.

• Experience with an array of multi-omic techniques including but not limited to RNA seq, cell-painting or genomics applications.

• Able to evaluate and interpret complex data, set and review bioanalytical strategies to support project decision making

• Organizational leadership experience, providing vision, direction, and fostering talent within your teams

• An understanding of the global pharmaceutical industry and the key value-creating processes within the industry.

• Proven publication and presentation record

• Exceptional verbal and written communication skills<