Assoc. Scientific Director, Antibody Engineering

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

Responsible for leading a team of protein engineers in the identification and optimization of antibody and other biologics therapeutics, including affinity maturation and improvement of developability. Responsible for leading multiple drug discovery programs, from concept to development candidate. Leads team in optimization of existing processes as well as in the introduction of novel technologies into workflows. Will collaborate closely with research and development analytical teams to ensure appropriate supply of material for analytical development and to ensure projects stay on track. Expected to work closely with multiple project teams to advise on all aspects of biologics discovery and development. Collaborates with CMC, Lead-Optimization, Translational Pharmacology, and other Research teams to develop novel therapies. Strategizes with key stakeholders, including Chemical Development, Product Development, Analytical Development, Clinical Trail Material Supply Chain, QA, and Regulatory CM to advance drug candidates through to clinical development.

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Your Contributions (include, but are not limited to):

• Leads a protein engineering team in discovering, assaying, engineering, reformatting antibodies and biologics

• Responsible for resource allocation to achieve team and project goals within a defined budget

• Actively manage and develop a high performing team of protein engineers

• Develop and deliver scientific presentations, prepare clear and concise technical reports, participate or lead project teams

• Contributes to development of policies, SOPs, and department strategies

• Monitor and incorporate the latest developments in the biologic therapeutic space for opportunities that will keep Neurocrine’s franchises current and competitive

• Presents data and strategies at varying levels across the company

• Other duties as assigned

Requirements:

• BS/BA in Analytical Chemistry or related discipline and 10+ years of experience in pharmaceutical research or development OR

• MS/MA in Analytical Chemistry or related discipline and 8+ years of experience

• PhD in Analytical Chemistry or related discipline and 5+ years of relevant experience; may include postdoc experience

• Previous managerial / functional management experience also required

• Industry leading knowledge of state-of-the-art protein engineering concepts and techniques

• Practical experience with affinity determination methods, and execution of antibody optimization campaigns using directed evolution screening platforms

• Protein expression, purification and analysis

• Gene manipulation techniques, including cloning, and use of gene expression manipulation technologies (ASO, siRNA, miRNA, AAV transduction)

• MAbs/bi specifics – Proven success in the ability to apply protein engineeri