Senior Clinical Supply Manager

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Title: Senior Clinical Supply Manager

Location: Conshohocken, PA

About the Role:
We are seeking a detail-oriented and experienced Senior Clinical Supply Manager to oversee the planning, coordination, and distribution of clinical trial materials. The Senior Clinical Supply Manager will ensure that investigational medicinal products (IMP) and other clinical supplies are delivered on time, in compliance with regulatory requirements, and aligned with study needs.

Key Responsibilities:

• Develop and execute clinical supply plans for multiple studies, ensuring timely availability of investigational medicinal products (IMP) and materials.
• Forecast supply needs and manage inventory levels to prevent shortages or overages.
• Collaborate with cross-functional teams, including Clinical Operations, Regulatory Affairs, and Quality Assurance to align supply strategies with trial requirements.
• Work with packaging vendors to coordinate production, labeling, packaging, and distribution of clinical trial materials.
• Monitor shipment logistics, including temperature-controlled storage and transport, ensuring compliance with Good Manufacturing Practices (GMP) and Good Distribution Practices (GDP).
• Maintain accurate documentation of supply chain activities, ensuring adherence to regulatory guidelines (e.g., FDA, EMA, ICH, GCP).
• Support Investigational Medicinal Product (IMP) release, reconciliation, and destruction processes.
• Identify and mitigate risks associated with supply chain disruptions.
• Optimize supply chain processes by implementing best practices and continuous improvement initiatives.

Qualifications & Experience:

• Bachelor's degree in a related field (e.g., Supply Chain Management, Life Sciences, Pharmacy, or Business)

• 8+ years of experience in clinical supply chain management within the pharmaceutical or biotechnology industry, familiarity with global clinical trial regulations and international supply chain challenges.

• Strong understanding of clinical trial operations, regulatory requirements, and GMP/GCP/GDP guidelines.
• Experience working with clinical packaging, labeling, and distribution vendors.
• Proficiency in supply forecasting and inventory management tools.
• Excellent project management and problem-solving skills.
• Strong interpersonal and communication skills to collaborate effectively with internal and external stakeholders.

• Ability to work in a fast-paced environment with shifting priorities.
• Experience with Interactive Response Technology (IRT) for clinical supply management.

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $152,000 - $186,000 per year.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual an