Senior Business Systems Analyst

Company Description

Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has commercially launched Guardant360®, Guardant360 CDx, Guardant360 TissueNext™, Guardant360 Response™, and GuardantOMNI® tests for advanced stage cancer patients, and Guardant Reveal™ for early-stage cancer patients. The Guardant Health screening portfolio, including the Shield™ test, aims to address the needs of individuals eligible for cancer screening.

Job Description

About the Role

We are seeking a Senior Business Analyst, Software to bridge the gap between product strategy and technical execution. This individual will work closely with Product Managers, Engineering Teams, and Clinical Stakeholders to translate complex business needs into clear, structured, and actionable technical requirements. The role will also offer opportunities to work on AI-driven insights and advanced analytics.

A strong analytical mindset is crucial for this role—this person should be able to dive deep into data, identify patterns, uncover insights, and find the ‘needle in the haystack’ to drive decision-making and optimize solutions.

Key Responsibilities

Requirement Analysis & Technical Translation

• Collaborate with Product Managers, Engineers, and Clinical Experts to understand business needs and convert product requirements into detailed technical specifications.
• Document user stories, workflows, data models, and system requirements, ensuring clarity and completeness for engineering teams.
• Work closely with developers to ensure requirements are technically feasible, scalable, and aligned with Guardant Health’s broader digital and data strategy.

Data-Driven Insights & Problem Solving

• Analyze large datasets to identify trends, anomalies, and key insights that impact product development and clinical decision-making.
• Utilize SQL, dashboards, and data analytics tools (like Tableau) to find patterns and drive data-backed product improvements.
• Work cross-functionally to validate hypotheses, ensuring solutions align with business needs and compliance requirements.

Cross-Functional Collaboration & Agile Execution

• Act as a liaison between business and engineering teams, ensuring alignment on priorities, feasibility, and implementation timelines.
• Support Agile development processes, including backlog refinement, sprint planning, and defining acceptance criteria.
• Ensure clear documentation and communication across teams, reducing ambiguity and increasing development efficiency.

System & Process Optimization

• Identify gaps in current systems and propose process improvements to enhance operational efficiency.
• Work on EMR integrations (Epic, OncoEMR, hospital networks) and LIMS (LabVantage preferred) to ensure seamless data flow between healthcare platforms.
• Help define test cases, validate functionality, and ensure alignment with regulatory and compliance standards (HIPAA, CAP/CLIA, FDA).

Qualifications

Required Qualifications

• 5+ years of experience as a Business Analyst, Technical Product Manager, or similar role in a software or healthcare tech environment.
• Strong analytical and problem-solving skills, with a data-driven mindset to identify trends, insights, and inconsistencies.
• Experience translating high-level product goals into structured technical requirements.
• Hands-on experience with SQL and data analysis tools to support investigative deep dives.
• Familiarity with APIs, cloud-based architectures (AWS preferred), and software development best practices.
• Excellent written and verbal communication skills, with the ability to interact with both technical and non-technical stakeholders.
• Experience in Agile/Scrum environments, writing user stories, and working with engineering teams.

Nice to Have

• Experience in Life Sciences, Healthcare, or HealthTech industries.
• Familiarity with EMR/EHR integrations (Epic, OncoEMR, HL7, FHIR).
• Understanding of LIMS systems (LabVantage preferred).
• Knowledge of regulatory frameworks such as HIPAA, CAP/CLIA, or FDA compliance.

Why Join Us?

At Guardant Health, you’ll be part of a mission-driven team working at the intersection of genomics, digital health, and data science. This is a unique opportunity to play a critical role in shaping the future of precision oncology by ensuring the right technical foundations for transformative digital solutions.

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