Clinical Systems Architect

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary
We are seeking a Clinical Systems Architect with strong Architecture and DevOps expertise to serve as a technical bridge between application development and IT infrastructure teams. This role requires deep knowledge of CI/CD pipelines, information security, networking, and cloud operations, while maintaining strong full-stack development capabilities. The ideal candidate will collaborate with Software Engineers, Architects, Engineering Managers, Product Managers, and IT teams to deliver secure, scalable, and high-availability solutions.

Job Responsibilities

• Lead the design and implementation of CI/CD pipelines with automated deployment strategies, SAST/DAST scanning, and infrastructure as code

• Architect and maintain cloud-native solutions across AWS, GCP, or Azure, ensuring optimal performance and cost efficiency

• Implement and manage security guardrails including authentication mechanisms, encryption protocols, and compliance frameworks (HIPAA, OIDC/OAuth 2.0)

• Design and optimize networking solutions for high-availability, load balancing, and secure data transmission

• Develop full-stack applications using Python and/or Node.js/Next.js with Vue.js or React

• Integrate with monitoring and observability tools (Sentry, Datadog, NewRelic, Grafana) for comprehensive application performance management

• Implement containerization strategies using Docker and Kubernetes for scalable deployments

• Design and maintain RESTful APIs with security-first principles

• Serve as the primary liaison between application development and IT teams (Networking, InfoSec, Cloud Operations)

• Automate infrastructure provisioning and deployment processes using DevOps methodologies

• Implement security scanning and monitoring throughout the development lifecycle

• Collaborate with cloud operations teams to ensure seamless releases and incident response

• Monitor incident tickets and determine resolution priority

• Perform code reviews and offer constructive feedback

• Provide technical/engineering support for existing applications, including code fixes

• Analyze and solve complex technical problems, ensuring code quality, performance, and scalability

• Collaborate with other departments (product management, quality assurance) for seamless product delivery

• Assist management with timelines, resource estimates, and delivery details

• Mentor and coach junior developers

• Perform other related duties as assigned

Required Qualifications

• Bachelor's degree in Computer Science, Software Engineering, or related field

• 5-7 years of DevOps & Infrastructure experience including expert-level proficiency in CI/CD methodologies and pipeline automation

• 5-7 years of Programming & Development experience with advanced Python programming and JavaScript/TypeScript expertise including Node.js, Vue.js, or React

• Strong experience with containerization (Docker, Kubernetes preferred)

• Proven track record in cloud architecture (AWS Lambda, SNS/SQS, S3, or equivalent GCP/Azure services)

• Comprehensive understanding of networking principles and security protocols

• Database design and optimization (MySQL, PostgreSQL, ORM technologies)

• API design and security implementation (REST, authentication, encryption)

• Deep knowledge of information security best practices and implementation

• Experience with security scanning tools (SAST/DAST) and vulnerability management