Executive Director, Head of Bioinformatics

Janux Therapeutics is seeking an Executive Director, Head of Bioinformatics, to build, lead, and scale a best‑in‑class bioinformatics and computational biology function supporting our discovery, translational, and clinical development programs across oncology and immunology.This is a hands‑on scientific leadership role for a seasoned bioinformatics leader who can operate as both strategist and technical expert. The Executive Director will define Janux’s bioinformatics vision, own multi‑omic and computational strategies from discovery through early clinical development, and serve as a key scientific partner across Research, Translational Medicine, Biometrics, and Clinical Development.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

• Define and own Janux’s bioinformatics strategy across discovery, translational research, and clinical development.
• Serve as a key scientific advisor to program teams, influencing strategy from discovery through clinical proof‑of‑concept.
• Establish scientific, technical, and data quality standards to support regulatory‑grade analyses where applicable.
• Translate complex computational results into clear scientific narratives for internal governance, executive leadership, and external audiences.
• Represent bioinformatics in senior‑level discussions and contribute to portfolio and platform‑level strategy.
• Lead hands‑on and/or directed analysis of complex, high‑dimensional clinical datasets, including ctDNA, CTC’s, flow, PK, ADA, NAb, tissue-based RNA/IHC, PET, CT (RECIST 1.1), and other comparable data types.
• Develop and oversee development, maintenance, and enhancement of scalable, reproducible bioinformatics dashboards, pipelines and analytical frameworks to support target discovery, mechanism‑of‑action studies, biomarker development, and patient stratification.
• Develop and implement computational strategies for data mining and exploration using statistical and machine learning methodologies.
• Partner closely with IT, Translational Medicine, Research, and Clinical teams to design and execute exploratory and hypothesis‑driven biomarker analyses.
• Support clinical programs by ensuring bioinformatics deliverables meet project timelines and expectations for data integrity, traceability, and documentation.
• Foster strong, collaborative relationships across functions and with external collaborators.
• Other duties as deemed necessary.

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS, AND ABILITIES

• Ph.D. (or equivalent experience) in Bioinformatics, Computational Biology, Biostatistics, Genomics, Computer Science, or a related discipline.
• 10+ years of biotech or pharmaceutical industry experience, with progressive leadership responsibility and a strong record of scientific impact.
• Demonstrated experience supporting translational and/or clinical development programs, preferably in oncology, immunology, or related therapeutic areas, e.g. cell & gene therapy.
• Strong programming skills (e.g., Python, R) and experience with reproducible research practices, data visualization, and modern analytical workflows.
• Proven experience evaluating and applying data science, machine learning, and AI methods in biological and clinical contexts.
• Ability to bridge computation and biology, translating complex analyses into actionable insights.

Job Type: Full-time Benefits:·         Annual bonus program·         Incentive stock option plan·         401k plan with flat non-elective employer contribution ·         Comprehensive medical insurance with 90-100% employer-paid premiums ·         Dental and vision insurance·         HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity) ·         Unlimited PTO ·         Generous holiday schedule; includes summer and winter company shutdown ·         Relocation assistance Schedule:·         Monday to Friday Work authorization:·         United States (Required) Additional Compensation:·         Annual targeted bonus % Work Location:·         On site (San Diego, CA) EQUAL OPPORTUNITY EMPLOYER:Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassme