Sr. Scientist

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The molecular genomics Sr. Scientist role is responsible for developing molecular assays and generation of research use  genomics data in support of BMS clinical trial analysis. This includes but is not limited to responsibility for genomics and gene expression profiling (GEP) biomarker assay technology/ platform selection, evaluation of in-house or vendor choice per assay use requirements, development, optimization, qualification/validation and/or execution of biomarker analysis for BMS translational medicine and clinical programs.

The Sr. Scientist candidate must have a strong technical background in PCR and NGS-based genomics and transcriptomics and its application in clinical programs, specific requirements are listed below:

• This position is 100% lab focused requiring onsite attendance.
• The individual is expected to work on multiple projects to support translational medicine and clinical programs.
• The individual works on genomics/transcriptomics strategy (assay, platform) per program requirements, protocol requirements, program biology and mechanism. Assays include but are not limited to broad genomic/GEP profiling, pharmacodynamic assays, target engagement assays, predictive, prognostic assays and technology platform development.
• Assay design and development: Develop the framework for assay development, qualification/validation protocols and timely, well-planned execution of assay and clinical analysis working with cross-functional teams. Additionally, the individual is expected to help assist with any troubleshooting of any assay performance-related activities. As an individual contributor operating within a matrix organization would facilitate the design, develop, optimize genomics and genetics biomarker assays and develop and execute the qualification/validation of these assays for clinical trial assays in house and/or potentially with external vendors.
• Key assay profiles likely to include NGS or PCR based gene expression systems, genotyping or variant analysis utilizing NGS or PCR or other methodologies.
• Evaluation of emerging technologies including new prep kits and developing expertise in assay methodology.
• A significant part of time will be spent overseeing assay/workflow development and generation/analysis of qualification/validation data. A strong understanding of assay development and fit for purpose assay qualification requirements will be essential.  
• In case of outsourced studies, the individual will provide subject matter expertise and oversight of assay development and execution of sample analysis including review of QC data, working in tandem with the TS&Dx Project Management team and other enabling cross-functional teams.
• Drafts experimental plans, including qualification protocols and reports, work instructions/SOPs, technology transfer documents, and study reports or summaries.
• Actively participate in internal/external collaboration and clinical study and biomarker execution teams as appropriate.
• Providing subject matter expertise for functional lead stakeholders as required.
• Accurate record keeping of experiments and procedures.
• Act as a technology evangelist and help assess (including conducting due diligence and pilot projects to assess feasibility) and onboard relevant technologies working with matrixed teams per program requirements.
• Work closely with data analysis teams as well as sample management and clinical operation teams on programs.  
• Provide mentorship and leadership within the MAD lab team.
• Work to develop a lean organization with highly efficient genomics processes and best practices.

Basic Qualifications:

• Bachelor’s Degree
  • 8+ years of academic and / or industry experience

Or

• Master’s Degree
  • 6+ years of ac