Postdoctoral Research Fellow Program, Quantitative Biosciences- Hybrid

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

We are seeking a talented and motivated Postdoctoral Scientist to join the Quantitative Biosciences department at our South San Francisco, CA site. In this role, you will launch an independent research project that leverages organotypic models to study cardiometabolic disease pathogenesis and therapeutic hypotheses, with a primary focus on vascular endothelial cell dysfunction. In collaboration with a highly networked interdisciplinary team, you will experiment with cutting-edge technologies (microfluidics, bioprinting, lab automation, etc.) to drive 3D in vitro/ex vivo cellular model development, probe novel disease mechanisms, and generate foundational knowledge in support of novel drug discovery efforts.

An ideal candidate should possess advanced cell biology and assay development skills, preferably with hands-on experience with various endothelial cell types or iPSC-derived cells for organoid generation or 3D model development. Successful candidates will be a self-starter who can bring critical thinking and creativity to solve complex scientific/technical challenges and positively contribute to a teamwork environment that is diverse and innovative. Our team values open communication, collaborative problem solving, and a collegial attitude.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Education Minimum Requirement:

• A Ph.D. in biological sciences, including cellular biology/pharmacology, biomedical engineering, genetics, or a related scientific discipline. Candidates who are expected to earn a Ph.D. within the 2024 calendar year shall be considered.

Required Experience and Skills:

• Relevant background in endothelial cell biology and assay development utilizing primary and/or iPSC derived cells.

• Expertise in building and evaluating organotypic in vitro models such as co-cultures, 3D spheroids or organoids, microphysiological systems, etc.

• Ability to independently design and execute complex biological experiments using a wide range of methods and techniques.

• Highly skilled in scientific data documentation, analysis, and interpretation.

• Ability to collaborate across disciplines and communicate effectively for both internal and external publications.

Preferred Experience and Skills:

• Prior experience with 3D image acquisition (confocal or high-content imagers) and AI/ML assisted data analysis (Harmony, Columbus, ImageJ, MATLAB, etc.).

• Familiarity with barrier function measurement techniques such as TEER.

• Molecular biology techniques such as qPCR, western blot, cloning, etc.

• Genetic manipulation of cells via transfection, CRISPR, viral integration, etc.

• Immunohistochemical or histology experience.

• Understanding of basic pharmacology principles.

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If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisiti