Senior Biostatistician (Remote Status)

Overview

The American Association for Cancer Research (AACR), with more than 61,000 laboratory, translational, and clinical researchers; population scientists; other health care professionals; and patient advocates residing in 143 countries and territories around the world, is the first and largest organization in the world dedicated to advances in all areas of high-quality, innovative cancer research.  Its mission is to prevent and cure all cancers.  The programs and activities of the AACR foster the exchange of new knowledge among scientists and physicians in cancer research as well as in related sciences.  The AACR publishes ten peer-reviewed scientific journals and an award-winning magazine for cancer patients and their loved ones; convenes topical scientific conferences and an annual meeting that draws more than 22,500 participants; offers educational workshops that train young investigators in a variety of scientific and clinical areas; funds research fellowships, career development awards, and research grants for both senior and junior investigators; raises public awareness of the progress in the biology, detection, diagnosis, treatment, and prevention of cancer; engages actively in advocacy for increased federal research funding and other national policies that accelerate progress against cancer; and interacts with regulatory agencies to support regulatory science and policy. Learn more at www.aacr.org.

 

About the Project

AACR Project Genomics, Evidence, Neoplasia, Information, Exchange (GENIE) is a publicly accessible international cancer registry of real-world clinico-genomic data assembled through data sharing between 20 of the leading cancer centers in the world. Through the efforts of strategic partners Sage Bionetworks and cBioPortal, the registry aggregates, harmonizes, and links clinical-grade, next-generation cancer genomic sequencing data with clinical outcomes obtained during routine medical practice from cancer patients treated at these institutions.

 

Job Summary:

AACR Project GENIE® is seeking an experienced Senior Biostatistician to provide statistical leadership across an international real-world clinico-genomic data consortium. This individual will serve as the primary statistical resource for the project, partnering with clinicians, scientists, data managers, and external collaborators to design, execute, and interpret observational research studies using real-world oncology data.

 

The successful candidate will independently develop statistical analysis plans, contribute to study protocols and publications, design appropriate analytical methodologies, and perform statistical programming in R. This role requires expertise in real-world data, including electronic health records, cancer registries, genomic sequencing data, and longitudinal clinical outcomes, as well as the ability to translate scientific questions into rigorous and reproducible statistical analyses.

 

This role is ideal for a senior biostatistician who enjoys working independently and leading the statistical design, programming, and interpretation of multiple concurrent studies within a collaborative multidisciplinary environment. The successful candidate will be a self-starter who takes initiative and balances big picture strategy with execution against project goals, bringing an entrepreneurial, visionary approach and the ability to conceive of, execute, and communicate innovative solutions. Additionally, the successful candidate should bring a strong passion for mission-driven causes and a commitment to advancing cancer research through high-quality, collaborative, statistical science.

Responsibilities

• Serve as the statistical subject matter expert for AACR Project GENIE, providing consultation to investigators, collaborators, and project leadership on study design and analytical strategy.
• Collaborate with investigators, pharmaceutical clients, and academic institutions to design observational studies using real-world clinico-genomic data
• Develop statistical analysis plans (SAPs), define study populations, cohorts, endpoints, and analytical methods
• Contribute statistical expertise to research protocols, study design, and publication planning
• Perform statistical programming and analyses using R
• Interpret results and contribute to manuscripts, abstracts, presentations and consortium reports
• Willing to experiment with new analytic methods as needed.
• Advise project leadership on appropriate statistical methodologies, and study design
• Ensure analyses are reproducible, well documented, and adhere to best practices
• Collaborate with data managers, investigators, and pharmaceutical clients to assess data quality, completeness and fitness for analysis
• Independently lead the statist