Senior Research Investigator

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Posted Job Title

Senior Research Investigator

Job Profile Title

Research Investigator, Senior

Job Description Summary

The Dominguez Lab seeks a Senior Research Investigator to study actin cytoskeleton mechanisms using structural, biochemical, and biophysical approaches, combining research and laboratory management responsibilities. Candidates should hold a PhD, have strong experience in protein biochemistry and molecular biology, and be highly organized and collaborative.

Job Description

Job Responsibilities Include:

• Conduct and contribute to research on actin and actin-binding proteins using structural, biochemical, and biophysical methods
• Perform molecular cloning and protein expression in E. coli, baculovirus–insect, and mammalian systems.
• Purify proteins using affinity tags and chromatography.
• Conduct biochemical assays, including isothermal titration calorimetry, pyrene–actin polymerization, and co-sedimentation assays.
• Participate in cryo-electron microscopy and protein structure studies (experience desirable but not required).
• Manage laboratory operations, including maintaining supplies, tracking inventories, and coordinating orders and shipments.
• Mentor and support graduate students and postdoctoral researchers.

· Additional duties as assigned.

Qualifications

• Doctor of Medicine, Doctor of Philosophy, and 5 to 7 years of postdoctoral experience is required.

• Strong organizational, written and verbal communication, and problem-solving skills required.

• Experience with laboratory management preferred.

• Familiarity with protein structure and/or cryo-EM techniques desirable.

This position is contingent upon continued funding.

Job Location - City, State

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$79,500.00 - $106,000.00 Annual Rate

Salary offers are made based on the candidate’s qualification