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Sr. Manager, Manufacturing and Technical Operations
KariusRedwood City, United Statesfull_timeVerifiedPosted 26 Nov 2025
About the role
About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions.
SummaryWe are seeking a Senior Manager to lead Karius’s growing Manufacturing and Technical Operations team. This role oversees the full end-to-end manufacturing lifecycle, including production planning, sourcing, inventory management, reagent and kit manufacturing, and quality control testing for existing products. The Senior Manager will also drive the development of manufacturing infrastructure, new production processes, qualification procedures, and tracking systems that enhance the scalability and robustness of reagent manufacturing. Key responsibilities include designing and establishing a dedicated manufacturing infrastructure, coordinating cross-functional activities to ensure operational goals are consistently achieved, and providing technical leadership to support and optimize reagent manufacturing workflows. The ideal candidate brings strong operational excellence, deep technical expertise in molecular biology, and the ability to build and scale robust, compliant manufacturing processes that support clinical, analytical, and commercial needs.
Why Should You Join Us?Karius aims to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company’s platform is already delivering unprecedented insights into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood, and helping industry accelerate the development of therapeutic solutions. The products Karius offers today are some of the most advanced solutions available to physicians who aim to deliver better care to many otherwise ineffectively treated patients. Our tests are the result of some incredible work done by our scientists, statisticians, engineers, and physicians, all driven by the same mission. You, as part of the Karius team, will be able to see how directly your work has a life-changing impact on people, and at scale.
Reports to: Senior Director, Assay Development and Manufacturing
Location: Redwood City, CA
Primary Responsibilities• Oversee daily operations of the reagent manufacturing function, including manufacturing scheduling, production execution, qualification testing, data analysis, troubleshooting, and resolution of technical and non-technical issues.• Lead the design and development of manufacturing infrastructure and management systems.• Provide hands-on technical leadership in manufacturing process development, qualification testing method development, and inventory management.• Develop, implement, and maintain tools and systems for tracking, trending, and reporting reagent and kit performance over time.• Collaborate with R&D to transfer, scale, and validate manufacturing processes and quality control test methods for product release.• Create and maintain manufacturing documentation, including batch records, job aids, qualification protocols, operating procedures, and design change controls, in compliance with ISO 13485 quality system requirements.• Collaborate with Procurement and Quality to support management of key suppliers and external manufacturers, including supplier quality oversight, vendor change assessments, secondary vendor evaluations, and inventory updates.• Support manufacturing strategy, capacity planning, equipment evaluation, and long-term operational scalability.• Drive continuous improvement initiatives to enhance efficiency, reliability, and cost-effectiveness across manufacturing operations.• Manage a team of Senior Research Associates and Scientists, providing mentorship, technical guidance, performance management, and professional development.
What’s Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work real
SummaryWe are seeking a Senior Manager to lead Karius’s growing Manufacturing and Technical Operations team. This role oversees the full end-to-end manufacturing lifecycle, including production planning, sourcing, inventory management, reagent and kit manufacturing, and quality control testing for existing products. The Senior Manager will also drive the development of manufacturing infrastructure, new production processes, qualification procedures, and tracking systems that enhance the scalability and robustness of reagent manufacturing. Key responsibilities include designing and establishing a dedicated manufacturing infrastructure, coordinating cross-functional activities to ensure operational goals are consistently achieved, and providing technical leadership to support and optimize reagent manufacturing workflows. The ideal candidate brings strong operational excellence, deep technical expertise in molecular biology, and the ability to build and scale robust, compliant manufacturing processes that support clinical, analytical, and commercial needs.
Why Should You Join Us?Karius aims to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company’s platform is already delivering unprecedented insights into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood, and helping industry accelerate the development of therapeutic solutions. The products Karius offers today are some of the most advanced solutions available to physicians who aim to deliver better care to many otherwise ineffectively treated patients. Our tests are the result of some incredible work done by our scientists, statisticians, engineers, and physicians, all driven by the same mission. You, as part of the Karius team, will be able to see how directly your work has a life-changing impact on people, and at scale.
Reports to: Senior Director, Assay Development and Manufacturing
Location: Redwood City, CA
Primary Responsibilities• Oversee daily operations of the reagent manufacturing function, including manufacturing scheduling, production execution, qualification testing, data analysis, troubleshooting, and resolution of technical and non-technical issues.• Lead the design and development of manufacturing infrastructure and management systems.• Provide hands-on technical leadership in manufacturing process development, qualification testing method development, and inventory management.• Develop, implement, and maintain tools and systems for tracking, trending, and reporting reagent and kit performance over time.• Collaborate with R&D to transfer, scale, and validate manufacturing processes and quality control test methods for product release.• Create and maintain manufacturing documentation, including batch records, job aids, qualification protocols, operating procedures, and design change controls, in compliance with ISO 13485 quality system requirements.• Collaborate with Procurement and Quality to support management of key suppliers and external manufacturers, including supplier quality oversight, vendor change assessments, secondary vendor evaluations, and inventory updates.• Support manufacturing strategy, capacity planning, equipment evaluation, and long-term operational scalability.• Drive continuous improvement initiatives to enhance efficiency, reliability, and cost-effectiveness across manufacturing operations.• Manage a team of Senior Research Associates and Scientists, providing mentorship, technical guidance, performance management, and professional development.
What’s Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work real
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