Senior Research Associate, Analytical Development

Company Summary:

Laronde is pioneering a platform that offers a completely novel way of modulating human biology via Endless RNA™ (eRNA). eRNA is a uniquely engineered RNA that can be programmed to express diverse proteins inside the body. Laronde is rapidly scaling to support the development of multiple programs across many disease areas. ​

Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. Laronde has a highly collaborative, dedicated culture, driven to achieve our vision of “making eRNA an essential class of medicines to everyone, everywhere”. To learn more, please visit the company’s website at https://www.laronde.bio.

Position Summary:

Laronde is seeking an enthusiastic, self-motivated, and highly organized Sr. Research Associate/Associate Scientist to join our Analytical Development (AD) team. The successful candidate will play a key role in the Separation Sciences group, and develop analytical methods based on UHPLC, HPLC, and Capillary Electrophoresis to support in process and release analytics. This position will involve close collaboration with the Process Development, Technical Operations and Platform teams to advance our novel Endless RNA (eRNA) Platform.

Key Responsibilities:

• Develop, optimize, and qualify analytical methods based on UHPLC, HPLC, and Capillary Electrophoresis instruments.
• Implement separation methods to analyze eRNA for in-process testing, purity testing, product characterization, impurity characterization, etc.  
• Oversee new analytical instrument evaluation, installation, and analytical method troubleshooting.
• Participate in phase-appropriate method qualification/validation and transfer to CRO.
• Collaborate within the AD team, as well as cross-functionally with the Process Development, Pre-Clinical Production, and Platform teams to plan and execute product characterization and comparability studies.
• Provide training to AD members and cross-functional teams on new and existing analytical methods.
• Document, review, interpret, and present data within AD and in cross functional forums.
• Capture experimental designs and results in Electronic Lab Notebook in a timely manner.  
• Author and review method development/qualification reports.

Required Qualifications:

• Master’s (preferred) in chemistry, biochemistry, or a related field with 3+ years of experience, or BS with 5+ years of experience in a relevant biotech/biopharma setting.
• Experience with a range of separation techniques (e.g. HPLC/UPLC, Capillary Electrophoresis) to analyze RNA, DNA, oligonucleotides, and/or other biologics.
• Proficient with good documentation practices, analytical data analysis, and technical reporting.
• Demonstrated ability to thrive in a closely collaborative environment and proactively seek cross functional input.
• Excellent communication and organizational skills.

Preferred Qualifications:

• Experience with LC-MS, Waters Empower, Sciex PA800 Plus, and charged aerosol detector (CAD).
• Analytical characterization of nucleic acid-based drug substances and formulated drug products (LNPs, etc)

 

Laronde is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Laronde does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Laronde or its employees is strictly prohibited unless contacted directly by Laronde’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Laronde, and Laronde will not owe any referral or other fees with respect thereto