Senior Principal Scientist, Cell Line Development

Job Description

The successful candidate should have industrial experience related to commercial CHO cell line development. Candidate must have an in-depth understanding of cell biology/molecular biology/systems biology and hands-on experience of molecular techniques, synthetic biology tools and next-gene sequencing. Candidate should demonstrate and stay up to date on the knowledge in genomics, transcriptomics, proteomics and genome editing technologies. Candidate must have experience in executing complex study designs requiring highly organized data collection and management

Primary Responsibilities:

• Serve as the subject matter expert in cell line development and technical lead to represent functional area for biologic pipeline programs

• Work independently, including proactive planning, trouble shooting and successful execution of complex experimental protocols for cell line development

• Complete and effectively manage multiple projects within timelines ensuring that all tasks and responsibilities are carried out according to high scientific and ethical standards.

• Interface and collaborate with other functional teams in Discovery, Process development, Analytics, Operation, CRO/CMO outsourcing in the planning, execution, and technical troubleshooting.

• Responsible for technical reports and relevant sessions of IND and BLA filing.

• manage a team of 4-5 scientists, mentoring and guiding team members on the completion of portfolio and technology projects.

• Publications in peer-reviewed scientific journals and external/internal presentations are expected

Position Qualifications:

Education Minimum Requirement:

• PhD in Molecular Biology, Cell Biology, Genetics or related Biological Sciences with a minimum of 8 years of cell line development or related experience in industry

Required Experience and Skills:

• Experienced in developing commercial cell line development (CLD) for recombinant protein expression.

• Experienced in coordinate CLD responsibilities for pipeline project and ensure timely communication between CLD and other functional areas within CMC team.

• Excellent project leadership skills in driving for results and innovation. Strong communication and interpersonal skills to work in team environment.

• Strong knowledge and record of scientific skills in molecular biology, systems and Synthetic biology.

• Experienced in regulatory filing and preparing relevant documentation

• Excellent oral and written communication skills

Preferred Experience and Skills:

• Strong management and leadership experience

• Experienced in next generation sequencing (NGS) platform and high-level understanding of NGS analysis pipeline setup analysis.

• Expertise of R and Python  

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