Scientist I/II, CRISPR Genome Editing

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?

Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

The Company:

Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.

Position Summary:

We are seeking a highly skilled and motivated Ph.D. Scientist with expertise in CRISPR genome editing to join our innovative research team. The successful candidate will lead efforts to generate cell lines with mutations of interest using CRISPR technology, contributing to the advancement of our drug discovery programs.

Responsibilities:

• Design and execute CRISPR-based genome editing experiments to generate cell lines with specific mutations for target validation and drug screening applications
• Optimize CRISPR protocols and workflows for efficient gene editing and generation of genetically modified cell lines
• Characterize edited cell lines using molecular biology techniques, including PCR, sequencing, and gene expression analysis
• Collaborate with cross-functional teams to support drug discovery projects, providing expertise in CRISPR technology and genetic engineering
• Stay current on the latest advancements in CRISPR genome editing and gene manipulation technologies, and apply relevant knowledge to research projects
• Mentor research associates and junior scientists in CRISPR techniques and experimental design

Qualifications:

• PhD. in Molecular Biology, Genetics, Biochemistry, or a related field with at least 1 year of industry experience in a biotech or pharmaceutical setting (level will be adjusted according to experience)
• Demonstrated expertise in CRISPR genome editing and genetic engineering, with a focus on generating cell lines with specific mutations
• Experience with mammalian cell culture techniques, including cell line maintenance, transfection, and selection of edited clones
• Proficiency in molecular biology techniques, such as PCR, cloning, and sequencing
• Strong analytical and problem-solving skills, with the ability to troubleshoot and optimize experimental protocols
• Excellent communication and collaboration skills, with the ability to work effectively in a team environment
• Prior experience in a pharmaceutical or biotechnology industry setting is preferred

 

Location: Cambridge, MA 

 

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at