Scientist - Gene Delivery and Editing Process Development

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Title: Scientist - Gene Delivery and Editing Process Development

Location: Seattle, WA

We are looking for a successful scientist who will directly employ techniques for the in vitro production of oligonucleotides, and biophysical and analytical tools to develop our next-generation gene edited therapies. An outstanding candidate will be driven by a desire to create, optimize, and define novel processes that are not currently utilized by BMS. 

Key Responsibilities: 

• Execute nucleic acid ligation reactions using “splint ligation” methodology 

• Execute in vitro transcription reactions to produce RNA 

• Execute downstream purification of crude RNA products using anion exchange chromatography, reverse-phase (RP) chromatography, and buffer exchange unit operations 

• Execute ion-pairing RP chromatography assays to measure RNA full-length product purity 

• Execute native and denaturing PAGE (or capillary electrophoresis, CE) assays 

• Execute Cas nuclease binding assays (fluorescence based) for various gRNA constructs 

• Actively participate and support lab maintenance and continuous improvement initiatives 

• Maintain accurate and detailed laboratory notebooks and documentation 

• Summarize and present data in group meetings and contribute to group discussions 

• Author technical memos and reports 

Qualifications & Experience:

• STEM degree with 2+ years of relevant industry experience 

• Experience working with, storing, and analyzing purified nucleic acids and proteins 

• Independently motivated, and possesses the ability to work creatively with limited resources 

• Ability to communicate clearly and concisely through oral presentation and technical writing 

• Ability to leverage literature, and internal and external resources to form hypotheses 

• Degree in chemistry, biochemistry, molecular biology, or bio-related field, preferred

• Experience with optimiz