Research Technician - Brown Lab

Primary Work Address: 1275 York Avenue, New York, NY, 10021

Current HHMI Employees, click here to apply via your Workday account.

About the Role:

The Brown Laboratory (www.thebrownlaboratory.com) is seeking a highly motivated and detail-oriented Research Technician to support our cutting-edge research in immune regulation. The lab investigates mechanisms of immune tolerance across host–microbiota interactions, autoimmunity, cancer, and early-life immune development. Recent work from the lab has defined the cell types and mechanisms that instruct peripheral regulatory T cell development and tolerance to the gut microbiota.

Led by physician–scientist Dr. Chrysothemis Brown, the lab bridges mechanistic studies in experimental models with translational human immunology, collaborating closely with Memorial Sloan Kettering Cancer Center (MSK) and the Hospital for Special Surgery. The Brown Lab is located in the state-of-the-art Zuckerman Research Center on the Tri-Institutional campus (MSK, Weill Cornell, and Rockefeller University) in New York City’s Upper East Side—an exceptional environment for scientific growth, collaboration, and career development.

This position is ideal for candidates who are interested in working 2 years prior to pursuing graduate or medical school, offering a unique opportunity to gain hands-on experience and mentorship in a leading immunology lab.

Application Instructions:

Please include—preferably as a single PDF:

• Cover letter describing your research interests and goals

• CV (including relevant technical skills and any publications)

• Names and contact information for at least two references

What You’ll Get

• Comprehensive Training in advanced techniques, including in vivo mouse handling, tissue processing, and high-dimensional flow cytometry

• Close Mentorship from senior lab members, with opportunities for skill development and project ownership

• Preparation for Graduate or Medical School, including career guidance and research experience in a world-class biomedical environment

• Publications and Authorship Opportunities, including potential for co-first author contributions

• Exposure to Translational Research through collaborations with clinical teams at MSK and HSS

• Collaborative, Supportive Environment that values teamwork, communication, and scientific curiosity

What You Will Do

• Conduct experiments using in vivo mouse models, including animal handling, dissections, and tissue processing

• Manage mouse colonies, including breeding and genotyping

• Perform immune phenotyping via high-dimensional flow cytometry

• Prepare samples for single-cell genomics workflows (scRNA-seq / scATAC-seq)

• Carry out molecular biology and microbiology experiments (e.g., bacterial cultures, genome editing)

• Maintain accurate records and protocols using an electronic lab notebook

• Collaborate closely with team members, contribute to lab meetings, and assist in training new members

What You Bring

• Bachelor’s degree in Biological Sciences, Biochemistry, Immunology, Microbiology, Molecular Biology, Genetics, or a related field

• Required: Experience with animal handling and mouse colony management

• Highly Preferred: Hands-on experience with flow cytometry and animal dissection / tissue processing

• Strong organizational and time management skills with the ability to thrive in a fast-paced lab environment

• Excellent communication skills and a team-oriented mindset — enjoys collaborating and contributing to shared goals

• Genuine enthusiasm for science, curiosity, and a desire to learn new techniques

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and pres