Research Associate

About Eidos Therapeutics & BridgeBio Pharma

Eidos Therapeutics, an affiliate of BridgeBio Pharma, is a Phase 3 developmental-stage biopharmaceutical company focused on addressing the large and growing unmet need in diseases caused by transthyretin, or TTR, amyloidosis, or ATTR. We seek to treat this well-defined family of diseases at their collective source by stabilizing TTR. Our investigational product, acoramidis (AG10), is an orally administered small molecule designed to potently stabilize TTR, a potentially best-in-class treatment aiming to halt the progression of ATTR diseases.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs. 

Our focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zurich, Switzerland, and are expanding across Europe. 

To learn more about our story and company culture, visit us at eidostx.com/ | https://bridgebio.com

Who You Are

The Research Associate will execute, analyze, and report results for biological assays for preclinical program. 

Responsibilities

• Laboratory operations related to enzyme activity and inhibition. Planning and execution of experiments to measure inhibitory activity of small molecule drug candidates against target proteolytic enzymes
• Adhere to company standards, and compliance in current industry standards and practices
• Adhere to safety regulations for handling and disposing of human plasma/serum and reagents
• Proper maintenance of laboratory notebooks and forms in accordance with company policies and practices. Routine maintenance, and upkeep of laboratory

No matter your role at BridgeBio, successful team members are:

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

• Education requirement  
  • Bachelor’s or Master’s degree in Biochemistry, Genetics, Molecular Biology or Pharmacology 
• Relevant Experience 
  • Enzyme assays  
  • 4-5 years in Pharmaceutical Diagnostic in R&D or GLP environment 
  • Knowledge of GLP practice desired 
• Skills
  • Immunoassay and biochemical assay 
  • Laboratory experience with Western Blotting and SDS-PAGE is a must. Basic knowledge of immunoassays and fluorescence biochemistry is preferred. Hands on experience in protease assays in plate format with colorimetric or fluorometric detection is desired. Ability to work with tissues for in vitro assays
  • Strongly self-motivated individual with attention to detail 
  • Good time-management skills  
  • Good interpersonal skills, flexibility and works well independently and within a team environment
• Travel  
  • Not required except physical laboratory presence during work week 
• This is not a remote work position