Principal Scientist, Platform Biology

About Rezo TherapeuticsRezo is a different kind of biopharma company.  Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.   Our Founders and members of the Board are a group of esteemed, world-class scientists from the University of California, San Francisco: Nevan Krogan, Kevan Shokat, Sourav Bandyopadhyay, Natalia Jura, as well as renowned biotech executives George Scangos and Norbert Bischofberger. These leaders bring with them a strong track record of amazing discoveries and scientific breakthroughs, leading to very successful companies and many FDA approved drugs. 
Capitalizing on our Series A of $78M from top-tier investors, we are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches. A list of seminal studies leading to our company's formation, published in the journal Science, can be found here.
Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities.  We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements.   If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us! 
We are seeking a highly enthusiastic and motivated Principal Scientist to join our Platform Biology team. This role is focused on the discovery and validation of new targets in oncology, in addition to supporting drug development efforts. Becoming a member of this team is an excellent opportunity to join Rezo at an early stage and help build the Platform function and the company from the ground up

What You'll Do:

• Develop and implement strategies to identify new targets in oncology by leveraging multiple platform technologies (proteomics, genetics, chemical biology and structural biology) together with computational teams to mine internal and external datasets 
• Lead development of prioritized targets knowledgebase, using publications, patents, news releases, and private data sources to expose critical development points for key targets
• Coordinate identification of target risks and opportunities; strategize and execute tasks to de-risk targets
• Partner with Platform, Discovery Biology, and other contributing departments to shepard new target opportunities into the Rezo  pipeline 
• Manage and analyze experimental data, interpret results, and prepare necessary materials for internal and external meetings and publications
• Communicate and collaborate across a diverse interdisciplinary research team
• Contribute to and balance multiple projects/studies in parallel in a fast-paced environment 
• Manage one or more direct reports, with potential to grow your team as the company scales

About You:

• PhD with a focus on Cancer Biology, Cellular/Molecular Biology, Biochemistry, or related field plus 7-10+ years work experience, with a minimum of 4 years in drug discovery/development OR BS in Biology, Biochemistry or related field plus 15+ years work experience, with a minimum of 8 years in drug discovery/development
• Strong background in oncology therapeutic target discovery and assessment
• Experience with and intimate knowledge of the use of cancer-specific and target databases to support ID efforts
• Extensive hands-on experience with target discovery methodologies (e.g. flow cytometry, Western blot analysis, ELISA, NGS, etc.)
• A sustained record of scholarly achievements, as evidenced by publications in high impact journals or through public disclosures and/or public presentations
• Excellent communication, organization, and interpersonal skills
• Excellent mentoring skills, with prior management experience strongly preferred
• Demonstrated ability to set the scientific direction for and lead a team
• Ability to strategize and collaborate with other leaders across teams/functions to identify the direction for their team
• Domain expert, scientific leader, or a combination of both
• Ability to solve problems whose solution is non-obvious to more senior leaders
• Ability to work without direction

Compensation at RezoThe expected starting salary range for this position based in San Francisco, California is $154,000 - $215,000.  Actual starting salary will be determined based on multiple job-related factors including a c