Principal Research Associate, Formulation Chemistry (CONTRACT)

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are a highly motivated and dependable Principal Research Associate who thrives in a collaborative and fast-paced environment. You have a team player mentality and excellent communication skills that will allow you to collaborate effectively as you work alongside your team, as well as cross-functionally within the organization. You are oriented and highly versatile in high-throughput formulations.

The Opportunity

The Principal Research Associate will report to the Senior Scientist, Discovery Chemistry, and be responsible for the formulation and characterization of oligonucleotides, peptides, conjugates, and other novel molecules. You will manage the chemical inventory and maintain a good experimental record in electronic lab notebooks. The ideal candidate will interpret and present research data and findings in internal scientific meetings as well as prepare procedures and technical reports. 

Responsibilities

• Formulate oligonucleotides, peptides, conjugates, and other novel molecules for in vitro and in vivo studies to support DM1 and other discovery projects.
• Coordinate with internal stakeholders to ensure that materials are available for maintaining the project timeline.
• Review formulation characterization results to meet sample release criteria.
• Troubleshoot experiments when problems arise.
• Coordinate with cross-functional teams for data and sample transfers.
• Organize and document all experimental data and connect with all related in vitro and in vivo.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• B.S. with 6+ years of relevant experience or M.S. degree with 4+ years relevant experience in Pharmaceutical Sciences, Chemistry, Biology, Bioengineering, or a related field.
• Hands-on experience with oligonucleotide, peptide, and conjugate formulations for in vitro and in vivo biological assays is required.
• Ability to execute pipetting tasks accurately and efficiently to maintain the integrity of experimental results.
• Experience with aseptic handling techniques is required.
• An understanding of laboratory safety and best practice is required.
• Hands-on experience with analytical instrumentation such as UV-Vis, HPLC/UHPLC, LCMS for formulation characterization is a plus.
• Attention to detail and the ability to thoroughly document experimental work in electronic lab notebooks (ELNs).
• Understanding of oligonucleotide/peptide chemistry as well as the knowledge of analytical chemistry is a plus.
• Excellent written skills to author SOPs and technical reports, and verbal communication skills to present internally and externally.
• A demonstrated ability to work independently with guided supervision as well as being a part of a multidisciplinary and cross-functional team while maintaining the highest ethica