Postdoctoral Research Scientist, Gene Therapy

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:

The Postdoctoral Research Scientist in Gene Therapy will participate in conducting preclinical stage Gene Therapy programs at Neurocrine using AAV vectors. Working with our Collaboration Partners and internal colleagues in Research, CMC, and Business Development, the individual will participate in work on new and existing programs.

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Your Contributions (include, but are not limited to):

• The primary role is to initiate and conduct a novel Gene Therapy research project

• Design and perform in vitro and in vivo studies in support of current and future Gene Therapy opportunities

• Prepare data summaries and present results to peers and colleagues at Neurocrine

• Be able to present data as appropriate at scientific meetings at the National and International level

• Other tasks as assigned

Requirements:

• Ph.D. degree in biology, life sciences or related discipline, with experience in the biotech/pharmaceutical industry OR with prior non-industry postdoc experience

• Experience with the application of gene therapy methods to animal experimental disease models. This includes experience with viral (preferably AAV) and/or non-viral gene delivery for upregulation of gene expression, downregulation, genome-editing or delivery of genetic material via lipid nanoparticles

• Knowledge about AAV vector design, capsid/cargo, serotypes, promoters, enhancers

• Experience or exposure to neuro-endocrinology or metabolism research will be a plus

• General knowledge about the function of the central and autonomic nervous systems and gastrointestinal system

• Experience in advanced experimental technologies and their utilization in the drug discovery process

• Experience with primary neurons and iPSC-derived neurons, and their use in assay development a plus

• In vivo experience working with animal models of disease

• Excellent critical analysis skills

• Assimilates data and research findings outside of Neurocrine for applicatio