Postdoctoral Research Associate

Summary
The Velasquez laboratory is seeking a highly motivated and creative candidate for a fully supported postdoctoral fellowship to develop immune-based therapie. Specifically, the research is aimed to develop T-cell-based therapies for pediatric high-risk leukemias. Studies are focused on using genetic engineering approaches to not only render immune cells cancer specific, but also improve their effector function. Genetically modified immune cells will be studied in preclinical models with special emphasis on how adoptively transferred cells interact with tumor cells, the tumor microenvironment, and resident immune cells. The goal of these studies is to gain mechanistic insights into the biology of genetically modified immune cells and translate these approaches into early Phase clinical testing.

Minimum Education Requirements
Successful applicants will have a strong publication record, excellent communication skills, and a Ph.D. or equivalent degree in molecular biology, cell biology, genetics, genomics, immunology, or a related area. To succeed in this position, you will have a strong immunology and/or cell biology background, with an emphasis on cellular immunology, and genetic manipulation of mammalian cells. Applicants with experience in generating and evaluating human or murine immune cells, gene editing, single cell transcriptomic, flow cytometry, and murine solid tumor models are strongly encouraged to apply.

Summary
The Velasquez laboratory is seeking a highly motivated and creative candidate for a fully supported postdoctoral fellowship to develop immune-based therapie. Specifically, the research is aimed to develop T-cell-based therapies for pediatric high-risk leukemias. Studies are focused on using genetic engineering approaches to not only render immune cells cancer specific, but also improve their effector function. Genetically modified immune cells will be studied in preclinical models with special emphasis on how adoptively transferred cells interact with tumor cells, the tumor microenvironment, and resident immune cells. The goal of these studies is to gain mechanistic insights into the biology of genetically modified immune cells and translate these approaches into early Phase clinical testing.

Minimum Education Requirements
Successful applicants will have a strong publication record, excellent communication skills, and a Ph.D. or equivalent degree in molecular biology, cell biology, genetics, genomics, immunology, or a related area. To succeed in this position, you will have a strong immunology and/or cell biology background, with an emphasis on cellular immunology, and genetic manipulation of mammalian cells. Applicants with experience in generating and evaluating human or murine immune cells, gene editing, single cell transcriptomic, flow cytometry, and murine solid tumor models are strongly encouraged to apply.

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