Manager, Financial Planning & Analysis (R&D)

About Summit:

Ivonescimab, known as SMT112, is a novel, potential first-in-class investigational

bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets with multifold higher affinity when in the presence of both PD-1 and VEGF.

Summit has begun its clinical development of ivonescimab in non-small cell lung cancer (NSCLC), with three active Phase III trials:

• HARMONi is a Phase III clinical trial which intends to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who have progressed after treatment with a 3rd generation EGFR TKI (e.g., osimertinib).

• HARMONi-3 is a Phase III clinical trial which is designed to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

• HARMONi-7 is a Phase III clinical trial which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC whose tumors have high PD-L1 expression.

Ivonescimab is an investigational therapy that is not approved by any regulatory authority in Summit’s license territories, including the United States and Europe. Ivonescimab was approved for marketing authorization in China in May 2024. Ivonescimab was granted Fast Track designation by the US Food & Drug Administration (FDA) for the HARMONi clinical trial setting.

Overview of Role:

Providing support to the Finance organization and reporting to the Head of R&D Finance. The role will support R&D primarily Clinical Trials. The role will support a global organization, with the ability to be in the office 4 days a week (Menlo Park, CA, Princeton, NJ or Miami, FL)

Role and Responsibilities:

• Support the annual budgeting, quarterly reforecasts and long-range plan processes for R&D functions and Clinical trials
• Develop and deliver monthly function, department and program financial reporting packages that provide actionable insights for R&D function leads
• Review material business terms & conditions on Clinical studies including vendor agreements, contracts and purchase requisitions
• Partner with Accounting to assist with monthly & quarter-end close processes for expenses and accruals, budget vs. actual analysis and compliance with internal controls
• Support ad hoc projects supporting strategic priorities, scenario planning, new indication planning, etc.
• Help drive continuous improvement within the Finance organization to streamline processes, improve communication, and enhance the flow of information to the business
• Ensure associated financial risks and opportunities both near and longer-term are identified and periodically reviewed
• All other duties as assigned

Experience, Education and Specialized Knowledge and Skills:

• Bachelors degree in Finance, Accounting, or related field required
• A minimum of 5+ years of experience in finance
• Experience in a pharmaceutical, biotech, or life sciences related industry required
• Demonstratable experience of working within a fast-paced finance function
• Strong Excel and financial systems experience, with the ability to manipulate and interpret key financial data
• High level of accuracy and attention to detail
• Demonstratable experience of prioritizing workload and managing multiple tight deadlines effectively under pressure in a fast-paced environment
• Excellent communication skills with the ability to forge strong internal and exter