Senior Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacokinetics & Pharmacometrics

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine   

Purpose: The Senior Principal Scientist will be a key member of discovery project teams and interact closely with biology, chemistry, and other drug metabolism and pharmacokinetic (DMPK) project members to help craft the most appropriate preclinical and early clinical studies and the associated quantitative model-based analyses to advise candidate selection and dosing recommendations. Modeling approaches used may include physiologically-based pharmacokinetic modeling, mechanistic PK/PD modeling, and/or systems pharmacology modeling to help (a) predict preclinical and clinical PK profiles (b) quantify exposure/ response relationships for target engagement biomarkers, efficacy, and potential adverse effects, and (c) guide in vivo and in vitro experimental designs that will be most informative for modeling.

We are searching for the best talent for a Senior Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics to be located in Spring House, PA or La Jolla, CA.

You will be responsible for:

• Applying Pharmacokinetic/Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies.
   
• Contributing to guide modeling and simulation strategies within the organization.

Qualifications / Requirements:

Education:

• PhD in Pharmacology, Engineering, Mathematics, Physics, or a related field with 6+ years of relevant industry experience OR a Master's degree with 8+ years of relevant industry experience is required.

Experience and Skills:

• Strong familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling is preferred.
   
• Proven skills in mathematical modeling and simulation, supported by peer-reviewed publications is highly desired.
   
• Excellent interpersonal, organizational, oral/written communication and teamwork skills are required.

Other:

• This position may require up to 10% travel.

The anticipated base pay range for this position is $137,000 to $235,750.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.

• Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
• Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
• Employees are eligible for the following time o