Senior Scientist, Translational Research

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients.  Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies.  With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome.  We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets.  We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.  We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Summary:

We are seeking a talented individual with oncology translational and/or discovery research experience to join the Translational Research team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, engaged, and creative scientist that can thrive in a highly matrixed organization to advance programs from candidate optimization through IND enabling activities and ultimately to Proof of Concept clinical trials. This individual will focus on exploring patient stratification hypothesis, identifying rational drug combinations, exploring mechanisms of action and mechanisms of resistance, and developing pharmacodynamic and target engagement assays.

Position Responsibilities:

In the role as a Senior Scientist within Oncology Translational Research, the ideal candidate will:

• Develop biomarker, pharmacodynamic and target engagement assays.

• Use current and new techniques to address drug mechanism of action and sensitivity/resistance studies.

• Leverage familiarity with antibody drug conjugate (ADC) or/and knowledge in DNA damage repair signaling pathways to obtain decision driving data and contribute to building of the translational strategy and plan for clinical implementation.

• Interact with project teams and contract laboratories for the design and oversight of molecular, cellular and/or in vivo studies.

• May be responsible for co-authoring non-clinical pharmacology study reports and scientific publications.

• Expected to understand departmental goals and development processes.

• Execute experiments independently, troubleshoot as needed, interpret and discuss data.

• Display excellent communication and interpersonal skills.

Experience =

Basic Qualifications:

• Bachelor’s Degree

• 7+ years of academic and / or industry experience

OR

• Master’s Degree

• 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

• 2+ of academic and / or industry experience