Senior Director, GHEOR (Field)

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Role Summary:

The Senior Director, GHEOR (Field) will advance the strategic objectives of GHEOR, Global Medical Affairs (GMA), and the broader organization by driving patient access through optimal pricing and reimbursement for Madrigal Pharmaceuticals’ medicines, with a primary focus on Rezdiffra.

This role directly impacts the achievement of global business objectives by providing strategic leadership and delivering robust evidence generation to demonstrate the value of Madrigal’s therapies in liver health. The Senior Director will lead the development and execution of real-world data (RWD) and real-world evidence (RWE) strategies that support Rezdiffra and the broader Madrigal portfolio, operating within a federated model that enables cross-enterprise collaboration and service delivery.

The Senior Director will, in coordination and alignment with the Field Medical and Health Systems Teams, and the Market Access Teams (Payer and KAD teams) lead HEOR engagements with national and regional payers and large health systems critical to supporting and delivering the value proposition for Madrigal’s products. This individual will be a leader in economic and public health value propositions for US payer customers and will be largely responsible for generating evidence (RWE, comparative effectiveness, PRO’s, productivity, etc.) to inform population health decision makers with respect to the value of Madrigals product portfolio. The Senior Director will work closely and compliantly with HQ HEOR, Medical, Commercial, Market Access, Legal and Compliance, by providing HEOR leadership on key matters pertaining to medical, commercial, and access initiatives with population health decision making. Additionally, the Senior Director will play a keep role in building and maintaining Thought leader (TL) and population health decision makers, to support the medical and HEOR strategy for Madrigals medicines.

This position is field-based and customer-facing, with an expectation of regular in-person engagement. The role follows a hybrid model, based in the U.S. (Midwest/West Coast), with an anticipated on-site or customer-facing presence three days per week. All incumbents are expected to comply with applicable Madrigal and divisional policies and procedures.

Key Responsibilities and Primary Activities: 

• Analytical Expertise and Technical Skills
  • Demonstrate strong analytical background in biostatistics, public health, or epidemiology with hands-on experience in real-world data (RWD) analysis
  • Leads collaborative customer outcomes research projects, provides input on HQ HEOR projects, and assists in the development and execution of HEOR/market access relevant activities (e.g., payer advisory boards, consultant, and HEOR projects).
  • Provides impactful feedback/information to internal stakeholders on emerging payer formulary/coverage and reimbursing trends.
• Real-World Evidence (RWE) and HEOR Research
  • Support real-world research projects in RWE and HEOR to generate actionable insights that inform business and clinical strategy
  • Develops and maintains clinical acumen related to disease-states of interest for Madrigal’s pipeline and marketed products.
  • Identifies and engages key stakeholders within the payer verticals (Insurers, PBMs, GPOs, Specialty Pharmacy, and Provider Networks) with key HEOR data on Madrigals medicines.
  • Establishes and maintains scientifically credible peer-to-peer scientific & collaborative research relationships with national & regional payers and managed care (e.g. Health plan P&