Principal Scientist – Covalency & Exploratory Chemical Biology

Job Description Summary

85% of the proteome is currently undrugged. You can join the effort to tackle a longstanding challenge in early drug discovery by identifying covalent small molecules that modulate the activity of these so far undrugged targets and pathways to positively impact human health. We are currently looking for a motivated and creative Principal Scientist to join an interdisciplinary team that combines chemical biology, covalent drug discovery, mass spectrometry, cell biology, and informatics technologies to tackle this challenge.

 

Job Description

Internal Position Title:  Principal Scientist I

Position location:  Cambridge, MA, onsite

About the Role:

85% of the proteome is currently undrugged. You can join the effort to tackle a longstanding challenge in early drug discovery by identifying covalent small molecules that modulate the activity of these so far undrugged targets and pathways to positively impact human health. We are currently looking for a motivated and creative Principal Scientist to join an interdisciplinary team that combines chemical biology, covalent drug discovery, mass spectrometry, cell biology, and informatics technologies to tackle this challenge.

Key Responsibilities:

• proposing, designing, and evaluating novel assays and chemotypes to tackle longstanding challenges in covalent ligand discovery

• effective communication and collaboration as a critical member of multi-disciplinary project teams in early stage drug discovery and covalency-enabled exploration of new modalities

• biochemical, biophysical, and cellular characterization of protein-ligand interactions, including MS-based characterization of covalent adducts on proteins

• medium-to-high throughput compound screening

Essential Requirements:

• PhD in Chemical Biology, Chemistry, Biochemistry, or Biological Science with at least 2 years of related postdoctoral and/or industry experience.

• A background in covalent ligand discovery with an emphasis in biophysics or cellular studies and a working knowledge of organic chemistry.

• Knowledge of the concepts governing compound binding affinity and reactivity, kinetics, and selectivity as well as experience with design and application of affinity- and reactivity-based chemical probes

• The ability to work collaboratively, with autonomy, and thrive in a multitasking environment

• Fluent English (spoken and written).

Desired Requirements:

• Experience with covalent chemoproteomics principles and data

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity and Inclusion / EEO: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $112,800 to $169,200/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discr