Principal Scientist I, Analytics & Separation Specialist, Oligonucleotide Research

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The Position

We advance science so that we all have more time with the people we love.

Roche Diagnostics is looking for a highly motivated and skilled Principal Scientist, Analytics & Separation Specialist in Oligonucleotide Research (Scientist) to support the development of advanced molecular diagnostics technologies. This role involves hands-on expertise in preparative chromatography and analytical techniques throughout the product development lifecycle, from early research to on-market support. As part of the Chemistry Team, you will have access to cutting-edge technologies and state-of-the-art instrumentation, enabling you to contribute meaningfully to advancements in molecular diagnostics. Your work will directly impact global health, pushing the boundaries of what's possible in the field of diagnostics.

• You have demonstrated experience purifying, analyzing, and characterizing complex oligonucleotides and related analogs.

• You have the ability to develop innovative analytical methods for reagents and assay performance, applicable in R&D and Operations; supporting scale-up and launch efforts.

• You have the ability to design and execute advanced troubleshooting experiments in coordination with collaborators; demonstrated experience developing creative assays to understand and detect system defects.

• You have the ability to support documentation transfer, specifically of prototype methods and documentation from research to development and manufacturing.

• You will serve as a subject matter expert and provide expertise across R&D departments (oligo synthesis & purification, assay development) and operations.

This position is based on-site in Pleasanton, CA.
Relocation benefits are not offered for this role. 

Who You Are:

(Requirements)

• You have a Bachelor's or Master’s Degree (preferred) in Chemistry, Biochemistry, Chemical Biology, Medical Chemistry (or related field) with 7+ years of industry experience; or a Ph.D. with 3+ years of relevant industry experience in Chemistry, Biochemistry, Chemical Biology, Medical Chemistry (or related field).

• You have comprehensive experience and problem-solving skills in UPLC/HPLC, ion pair chromatography, ion exchange, mass spectrometry, absorption, and fluorescence spectroscopy.

• You are proficient in oligonucleotide purification and characterization.

• You have demonstrated experience in DNA, RNA, non-natural modifications, and dye-modifications; you demonstrated experience in designing and optimizing analytical assays.

• You have demonstrated communication and organizational skills, including technical writing skills for detailed documentation / report preparation; excellent verbal and written communication skills for effective team collaboration.
   

Preferred:

• You have proficency organizing and maintaining a research laboratory.

• You have experience with automated DNA synthesis, phosphoramidite chemistry, and click-chemistry.

• You have working knowledge of PCR and/or other amplification technologies
   

This position is based on-site in Pleasanton, CA.

Relocation benefits are not offered for this role. 

The expected salary range for this position based on the primary location of Pleasanton, CA is $93,800 - $202,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This position also qualifies for the benefits detailed at the link provided below.

[Benefits]

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcar