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Manager/Sr. Manager, Human Resources

Oruka Therapeutics
Menlo Park, United Statesfull_timeVerifiedPosted 8 Jul 2026
💰 $187,000/yr($146,000/yr$187,000/yr)

About the role

About Us: 

Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases. Oruka’s mission is to offer patients suffering from chronic skin diseases like plaque psoriasis the greatest possible freedom from their condition by achieving high rates of complete disease clearance with dosing as infrequently as once or twice per year. Oruka is advancing a proprietary portfolio of potentially best-in-class antibodies that were engineered by Paragon Therapeutics and target the core mechanisms underlying plaque psoriasis and other dermatologic and inflammatory diseases. For more information, visit www.orukatx.com

As we build our core team, we're seeking top talent in different functional areas who are not just looking for a job, but an opportunity to be part of something bigger.  Someone who is passionate about making a difference and eager to contribute to establishing an engaged, inclusive, and positive company culture.  

Manager/Sr. Manager, Human Resources

Location: Hybrid - Menlo Park, CA (3 days onsite/week)

Position Summary

Reporting to the Senior Director, Human Resources, the Manager/Sr. Manager, Human Resources will serve as a trusted HR generalist who supports the day-to-day execution of key HR programs and operations. This hands-on role partners closely with the Senior Director to deliver operational excellence across the employee lifecycle, including recruiting support, onboarding, HR operations, benefits administration, leave management, compliance, performance management administration, and employee engagement.

The ideal candidate is an organized, collaborative HR professional who enjoys working in a growing organization, exercises sound judgment, and is committed to providing outstanding service to employees and managers while continuously improving HR processes and programs.

Key Responsibilities

Recruiting & Onboarding

  • Partner with the Talent Acquisition team and hiring managers to coordinate recruiting activities, interview scheduling, offer preparation, and other aspects of the hiring process.
  • Coordinate new hire onboarding and orientation to ensure a seamless and engaging employee experience.
  • Serve as a primary point of contact for new hires during the onboarding process.
  • Maintain job descriptions and applicant tracking system information in partnership with Talent Acquisition.
  • Prepare recruiting reports and hiring metrics as needed.

HR Operations

  • Serve as a resource for employees by responding to routine HR-related questions and directing more complex matters to the Senior Director, Human Resources as appropriate.
  • Support the Senior Director and managers in the consistent administration and communication of HR policies, programs, and processes.
  • Coordinate performance management activities, including review cycles, goal-setting processes, communications, and documentation.
  • Maintain HRIS data integrity and prepare reports, metrics, and analytics as needed.
  • Administer employee lifecycle transactions, including hires, promotions, transfers, status changes, and separations.
  • Maintain personnel files and HR documentation in compliance with company policies and applicable regulations.
  • Coordinate HR compliance activities, including I-9 administration, personnel record audits, required postings, recordkeeping, and support for policy updates.
  • Assist with planning and executing employee engagement initiatives, recognition programs, learning opportunities, and company events.
  • Identify opportunities to improve HR processes, workflows, and employee experience through continuous process improvement.

Benefits & Leave Administration

  • Coordinate benefits administration in partnership with the company’s PEO and benefit providers.
  • Serve as the primary internal contact for employee benefits questions and support annual open enrollment activities.
  • Coordinate leave of absence administration, including FMLA, ADA, parental leave, disability, and applicable state and local leave programs.
  • Track leave requests, documentation, eligibility, and return-to-work activities while partnering with the PEO, payroll, employees, and managers to ensure accurate administration.
  • Support compliance with applicable federal, state, and local employment laws related to benefits and leave administration.

Qualifications

  • Bachelor’s degree required.
  • 5+ years of progressive Human Resources experience, preferably as an HR Generalist or HR Operations professional in a biotech, life sciences, or ot

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Company

Oruka Therapeutics

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