Principal Scientist - ADC Pharmacology

Use Your Power for Purpose

At Pfizer, our purpose is to deliver breakthroughs that change patients’ lives. Your work will directly impact the development of therapies and vaccines that improve patients' lives globally. By leveraging advanced science and cutting-edge technologies, you will play a crucial role in transforming innovative ideas into life-changing medical solutions. Whether you are involved in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, your contributions will be vital in accelerating the delivery of top-tier medicines to patients worldwide.

What You Will Achieve

The Pfizer Oncology Research Unit is seeking a Principal Scientist to join our ADC Pharmacology team. The candidate will join an interdisciplinary and highly collaborative team to support and advance our preclinical ADC pipeline. The ideal candidate will have a strong background in cell and molecular biology, in vitro pharmacology, and automating the drug discovery process.

In this role, you will:

• Develop and Standardize ADC Screening Assays: Design, optimize, and validate in vitro screening assays to evaluate the mechanism of action of ADCs and ADC payloads.

• Implement and Optimize Automation Processes: Develop, implement, and continuously improve automated screening processes to enhance efficiency, accuracy, and throughput for ADC screening. This includes integrating robotics, software and data management systems to streamline workflows and reduce manual intervention.

• Collaborate with Cross-Functional Teams: Work closely with other scientists, researchers, and departments to ensure the successful progression of ADC projects.

• Manage CRO Partnerships: Oversee and coordinate with Contract Research Organizations (CROs) to develop and execute ADC screening programs. This includes defining project scopes, ensuring adherence to timelines and budgets, and quality control.

• Mentor and Train Junior Staff: Provide guidance and training to junior scientists and technicians in ADC screening techniques and best practices.

• Stay Current with Industry Trends: Keep up to date with the latest advancements in ADC technology and screening methodologies to ensure the company remains at the forefront of the field.

• Prepare and Present Reports: Compile comprehensive reports and present findings to stakeholders, including senior management and external partners.

Here Is What You Need (Minimum Requirements)

• BS with at least 12 years of experience or MS with at least 9 years of experience or PhD with at least 4 years of experience.

• Expertise in a variety of cell-based assays and technologies, including luminescence-based cell viability/cytotoxicity assays, HTRF, AlphLISA, HiBiT, and imaging.

• Experience in the development and standardization of in vitro cell-based screening assays to facilitate lead selection, including establishment of metrics and acceptance criteria for monitoring assay performance.

• Experience automating drug discovery workflows.

• Experience managing an independent research program with minimal supervision .

• Demonstrated ab