Sr. Associate Scientist/Associate Scientist

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

 

Legend Biotech is seeking a Sr. Associate Scientist/Associate Scientist as part of the R&D team based in Philadelphia, PA.

Role Overview

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of immunotherapy in the treatment of multiple myeloma.
This role supports early-stage development of engineered Lentiviral vectors by developing and executing analytical methods and testing strategies that enable candidate evaluation and selection. The position will generate critical, decision-driving data across exploratory phases and partner closely with cross-functional stakeholders, including Quality, to ensure analytical readiness as programs advance toward impactful gene therapies at Legend Biotech.

Key Responsibilities

• Perform Lentiviral vector (LVV) functional titration through transduction and flow cytometry.
• Quantify LVV genetic payload concentration via dPCR.
• Determine LVV protein concentration determination via ligand binding assays (ie. ELISA, MSD).
• Support method development, qualification and technology transfer across internal teams.
• Prepare and deliver analytical technical reports, data summaries and presentations.
• Enable strong across cross-functional execution through clear communication and data delivery across internal and partner teams.
• Maintain an organized, compliant laboratory environment to ensure consistency, traceability, and data integrity.
• Troubleshooting routine assay using data-driven root-cause approach, document results, and coordinate corrective actions with senior staff as needed.

Requirements

• BS degree with 3+ years relevant industry experience; MS degree with 1+ year or relevant industry experience; or PhD with +0 years of relevant industry experience in biochemistry, virology, molecular biology, cell&gene therapy, or a related field.
• Core technical foundation: Working knowledge of cell biology, biochemistry, and molecular biology concepts, including basic kinetic principles relevant to assay performance.
• Hands-on laboratory capability: Demonstrated ability to execute routine wet-lab experiments with attention to detail, consistency, and reproducibility.
• Data skills: Ability to analyze, interpret, and summarize experimental data: maintain accurate documentation and traceability.
• Communication: Clear written and verbal communication skills, including the ability to share results in reports, summaries, and presentations.
• Cross-functional mindset: Ability to work effectively with internal and cross-functional partners and respond to shifting priorities.
• Quality and compliance: F