Associate Scientist, Immunology

Jasper is a clinical-stage biotechnology company developing briquilimab, a novel antibody targeting c-Kit (CD117) as a therapeutic for chronic mast and stem cell diseases. Jasper is currently conducting clinical studies of briquilimab as a treatment in patients with CSU or with CIndU and is initiating a clinical study in patients with asthma. Briquilimab is also currently in clinical studies as a treatment for patients with LR-MDS and as a conditioning agent for cell therapies for rare diseases. To date, briquilimab has a demonstrated efficacy and safety profile in more than 160 dosed participants and healthy volunteers, with clinical outcomes in CIndU, and as a conditioning agent in severe combined immunodeficiency (SCID), acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), Fanconi anemia (FA), and sickle cell disease (SCD).

Role Description

• We are seeking for a highly motivated, enthusiastic, and organized Associate Scientist to join Jasper’s preclinical in vivo pharmacology team. The role focuses on developing, implementing, and executing high-throughput cell-based assays and in vivo proof-of-concept experiments. The ideal candidate will possess strong hands-on laboratory skills and a thorough understanding of scientific principles, experimental precision, and data integrity. Excellent communication skills, attention to detail, and the ability to thrive in a dynamic, fast-paced, and collaborative environment are essential for success in this role. 

Key Responsibilities

• Independently execute a variety of in vitro high-throughput cell-based functional assays and in vivo animal studies, adhering to project timelines and objectives.
• Contribute to IND-enabling preclinical studies, including in-house assay development, maintenance of multiple cell lines, and investigation of proof-of-concept in vivo models.
• Design and optimize new study protocols with general guidance and execute experiments independently.
• Analyze and interpret scientific results with general supervision, providing timely answers to key scientific questions.
• Collaborate with cross-functional teams supporting data analysis and contributing to both internal and external scientific discussions.
• Present findings at individual, project, and department meetings, and draft detailed scientific reports.
• Maintain thorough records of experimental designs, procedures, and results.
• Troubleshoot experimental challenges and instrumentation issues with guidance as needed.
• Manage lab reagent inventory and ensure timely ordering of supplies.
• Coordinate and prioritize tasks across multiple projects, demonstrating effective planning and organization. 

Qualifications

• Bachelor’s degree in Immunology, Cell or Molecular Biology, Biological Sciences, or a related field with 5+ years of relevant experience in academia or industry, or a master’s degree with 3+ years of experience.
• At least 2 years of hands-on experience in the pharmaceutical or biotechnology industry is preferred.
• Extensive experience with FACS and multi-color flow cytometry, including panel design and data analysis, is essential. Proficiency in tissue cell isolation and experience with single-cell RNA sequencing are highly desirable.
• Proficiency with high-throughput cell-based functional assays and MSD platforms is strongly preferred.
• Experience in development animal models is an advantage.
• Proficiency in aseptic mammalian cell culture techniques is required, with additional experience in hematopoietic stem cell and primary immune cell culture considered an advantage.
• Strong skills in using data analysis tools such as FlowJo and GraphPad Prism are required.
• Strong organizational skills and meticulous record-keeping abilities are essential.
• Demonstrated ability to thrive in a collaborative team environment, coordinating tasks across multiple projects to meet deadlines.
• Strong verbal and written communication skills, with the ability to manage timelines effectively.
• Excitement and flexibility to work in a dynamic, fast-paced biotech setting.

We offer our employees comprehensive benefits.Jasper is an Equal Opportunity Employer and does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other characteristic protected by applicable law. Company Values:·       Respect·       Collaboration·       Integrity·       Responsible·       Excellence·       Acknowledgment Mission:Our mission is to make safer and potentially curative therapy possible for more patients in need. We are bringing together a team of high performing biotech professionals, leading ac