Senior Scientist - siRNA Bioanalysis & Mechanistic Studies

Career Category

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist - siRNA Bioanalysis & Mechanistic Studies

What you will do

Let’s do this. Let’s change the world. In this vital role you will add to our diverse team in Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences (PKDM-BA) to advance our growing siRNA research portfolio. You will contribute to the execution of innovative bioanalytical platforms to measure siRNA in preclinical samples, both in vitro and in vivo, for characterizing ADME and elucidating pharmacokinetics and pharmacokinetic-pharmacodynamic relationships. You will also work independently and in teams to design and perform mechanistic studies for siRNA discovery research programs to support clinical candidate selection and regulatory applications.

• Independently and collaboratively conduct bioanalysis of siRNA therapeutics in preclinical samples (in vitro and in vivo)
• Work independently and in teams to establish innovative in vitro ADME assays for characterizing siRNA mechanism of action and generate high-quality, mechanistic insights to support discovery programs
• Work independently and in teams to design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of siRNA therapeutics
• Build strong interdepartmental relationships and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline

Or

Master’s degree in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience

Or

Bachelor’s degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience

Preferred Qualifications:

• Extensive knowledge of siRNA therapeutics, particularly within the context of ADME and pharmacokinetics
• Proven experience in designing and executing “fit-for-purpose” mechanistic assays to address key scientific questions related to siRNA therapeutics
• Hands-on experience with ligand binding assays (specifically immunoassay and hybridization assays), LC/MS bioanalytical platforms, and nucleic acid quantification techniques (RT-qPCR or RT-ddPCR)
• Strong critical thinking, problem-solving, and data interpretation skills
• Excellent written and verbal communication skills

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spendi