Manager, Software Engineering

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.

Job Description

About Guardant Health

Guardant Health is a leading precision oncology company on a mission to conquer cancer through data. We develop innovative digital and data-driven solutions that empower clinicians and patients across the continuum of cancer care. Our software and platform engineering teams are foundational to enabling seamless integration of our genomic testing with healthcare providers, hospital systems, and laboratory partners around the country.

About the Role

We are seeking a Manager, Software Engineering to lead a highly collaborative team focused on clinical data integrations, EMR connectivity, and partnerships with hospital networks and reference labs. This is a Palo Alto–based leadership role that combines technical depth, team management, and stakeholder engagement—both internal and external.

You’ll be responsible for building and scaling cloud-native integration platforms, primarily using Java, MuleSoft, and AWS, to ensure Guardant’s digital infrastructure enables seamless interoperability with Epic, OncoEMR, hospital systems, and third-party labs. This role is critical to driving clinical adoption, operational efficiency, and data reliability across Guardant’s enterprise offerings.

Key Responsibilities

Team & Project Leadership

• Lead and mentor a team of backend and integration engineers focused on data exchange between Guardant and external clinical systems.

• Oversee delivery of EMR integrations, including Epic, OncoEMR, and other hospital EHR platforms.

• Drive development of scalable services and APIs that enable lab partnerships and external data connectivity.

Architecture & Execution

• Architect and scale MuleSoft-based integration flows and microservices that manage clinical and lab data pipelines.

• Ensure solutions are cloud-native, deployed on AWS/Kubernetes, and align with Guardant’s data security, compliance, and observability standards.

• Drive cross-functional initiatives by collaborating with Product, Clinical, Commercial, and Compliance teams.

External Stakeholder Engagement

• Serve as a technical point of contact for reference labs, hospital networks, and third-party integration partners.

• Work closely with external IT and data teams to define interface requirements, manage onboarding, and troubleshoot connectivity issues.

• Represent the engineering organization in strategic partner discussions, ensuring technical feasibility and long-term scalability.

Operational & Engineering Excellence

• Champion engineering best practices including CI/CD, test automation, observability, and resiliency.

• Monitor integration KPIs and operational metrics to ensure ongoing reliability and performance of partner-facing systems.

• Collaborate with peer leaders across Palo Alto and India to ensure delivery alignment and team health.

Qualifications

• 10+ ye