Senior Biostatistician

Site: The General Hospital Corporation

 

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

 

Massachusetts General Hospital (MGH) is the largest research hospital in the United States with an annual research budget of over one billion dollars. The Neurological Clinical Research Institute (NCRI) at MGH was formed in 1994 by Dr. Merit Cudkowicz to help foster clinical research in the Department of Neurology and conduct clinical research in neurological disorders. Under the direction of Drs. James Berry, Sabrina Paganoni, and Suma Babu, NCRI functions as a Clinical and Data Coordination Center for research studies and therapeutic trials, including the HEALEY ALS Platform Trial and the MyMatch Trial. NCRI also serves as the Coordination Center for the Network of Excellent in ALS (NEALS) consortium and the NeuroNEXT network. Research at NCRI is supported by a Biostatistics group that includes multiple faculty statisticians, an operational director, and staff biostatisticians and statistical programmers. The group is supplemented by close collaborations with MGH Biostatistics and with colleagues at the Departments of Biostatistics and Epidemiology at the TH Chan School of Public Health at Harvard University.

MGH NCRI is seeking qualified applicants with master’s degrees in Biostatistics or a related field to serve as a Senior Biostatistician within the NCRI Biostatistics group. This is a unique role for a biostatistician who enjoys hands-on, cross-disciplinary work in a mission-driven setting. The position offers the chance to shape the design, conduct, and analysis of important research while working with a diverse team across academia, industry, and regulatory bodies. While housed within a renowned academic institution, the position offers the fast-paced, solution-oriented environment of industry and is ideal for a candidate who thrives on meaningful real-world applications.

Job Purpose
The Senior Biostatistician will be responsible for assisting statistical operations, including design, analysis, validation, and reporting of data to support clinical research and investigational product development. The individual will work closely with faculty biostatisticians and clinical investigators on a variety of projects focused on neurodegenerative diseases including academic and FDA-regulated clinical trials, observational studies, and registries. The individual will ensure the application of rigorous statistical methods and error-free statistical programming (using SAS and R) to produce accurate, reliable, and reproducible results. The individual will be expected to work closely with other team members to achieve larger goals while also taking ownership of projects and tasks and independently identifying areas that require additional attention or improvement in both their own and the team’s work.

PRINICIPAL DUTIES AND RESPONSIBILITIES:
• Develop statistical analysis plans for clinical trials, observational studies, and other biomedical research projects
• Conduct statistical analyses for clinical trials, observational studies, and registry data, including analyses of longitudinal outcomes, survival data, and other complex study designs using appropriate statistical models (e.g., mixed-effects models, survival models); begin to oversee biostatisticians and/or statistical programmers
• Generate reports of study progress, including reports for data and safety monitoring boards, and assist in the design of these reports
• Develop programs and guide efforts to perform robust data manipulation and error detection to ensure data integrity
• Assist in power calculations, determine sample size requirements, and advise on experimental design
• Assist and contribute to statistical analyses for scientific manuscripts, including drafting statistical methods sections, preparing tables and figures, and collaborating with investigators on interpretation and presentation of results
• Assist in the design of clinical studies and review protocols for statistical considerations
• Provide statistical guidance for grants and other funding proposals
• Engage in professional development opportunities

SKILLS & COMPETENCIES REQUIRED:
Applicants should meet the following qualifications:
• Masters (MS/MA) in Biostatistics, Statistics, Epidemiology, Computer Science, Mathematics, Engineering, Life Science, or related field.
• 3+ years of professional experience in academic medicine or pharmaceutical